U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ryr2b ryanodine receptor 2b (cardiac) [ Danio rerio (zebrafish) ]

Gene ID: 568463, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ryr2bprovided by ZNC
Official Full Name
ryanodine receptor 2b (cardiac)provided by ZNC
Primary source
ZFIN:ZDB-GENE-061226-3
See related
Ensembl:ENSDARG00000003706 AllianceGenome:ZFIN:ZDB-GENE-061226-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ryrbb
Summary
Predicted to enable ryanodine-sensitive calcium-release channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum and striated muscle contraction. Predicted to act upstream of or within calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be part of calcium channel complex. Predicted to be active in Z disc; endoplasmic reticulum; and sarcolemma. Is expressed in cardiac muscle; heart; heart primordium; and heart tube. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ryr2b in Genome Data Viewer
Location:
chromosome: 17
Exon count:
103
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (20009131..20118242, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (19994151..20093214, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene formin 2a Neighboring gene cholinergic receptor, muscarinic 3a Neighboring gene microRNA mir-2187 Neighboring gene actinin, alpha 2b Neighboring gene prolyl 4-hydroxylase, alpha polypeptide I b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Hirata H, et al. Development, 2007 Aug. PMID 17596281
  2. Interactions among ryanodine receptor isotypes contribute to muscle fiber type development and function. Chagovetz AA, et al. Dis Model Mech, 2019 Sep 18. PMID 31383689, Free PMC Article
  3. Evolution of Vertebrate Ryanodine Receptors Family in Relation to Functional Divergence and Conservation. Ding Z, et al. Int Heart J, 2017 Dec 12. PMID 29151485
  4. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Darbandi S, et al. Comp Biochem Physiol B Biochem Mol Biol, 2009 Dec. PMID 19755169
  5. Influences of domoic Acid exposure on cardiac development and the expression of cardiovascular relative genes in zebrafish (Daniorerio) embryos. Hong Z, et al. J Biochem Mol Toxicol, 2015 Jun. PMID 25691335

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ryanodine receptor 2
Names
ryanodine receptor 2b protein
ryr2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    20009131..20118242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214574.1 → XP_068070675.1  ryanodine receptor 2 isoform X1

    Related
    ENSDARP00000134589.1, ENSDART00000165606.2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394980.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    298398..321954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473092.2 → XP_021328767.1  ryanodine receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PCJ9
    Conserved Domains (2) summary
    pfam00520
    Location:687 → 847
    Ion_trans; Ion transport protein
    pfam06459
    Location:318 → 568
    RR_TM4-6; Ryanodine Receptor TM 4-6

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394981.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1979..94917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218849.1 → XP_068074950.1  ryanodine receptor 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools