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lipea lipase, hormone-sensitive a [ Danio rerio (zebrafish) ]

Gene ID: 568368, updated on 2-Nov-2024

Summary

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Official Symbol
lipeaprovided by ZNC
Official Full Name
lipase, hormone-sensitive aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-734
See related
Ensembl:ENSDARG00000063037 AllianceGenome:ZFIN:ZDB-GENE-060503-734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hsl; lipe; si:dkey-3n22.7
Summary
Predicted to enable sterol ester esterase activity and triacylglycerol lipase activity. Predicted to be involved in triglyceride catabolic process. Predicted to act upstream of or within cholesterol metabolic process and lipid catabolic process. Predicted to be located in caveola and lipid droplet. Predicted to be active in cytosol. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See lipea in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (10794042..10829598)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (10875074..10910681)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A3, tandem duplicate 1 Neighboring gene solute carrier family 9 member A3, tandem duplicate 2 Neighboring gene si:dkey-3n22.9 Neighboring gene uncharacterized LOC137488480 Neighboring gene translocase of outer mitochondrial membrane 40 homolog, like Neighboring gene apolipoprotein A-IV a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Mineralocorticoid Receptor Functions as a Key Glucose Regulator in the Skeletal Muscle of Zebrafish. Faught E, et al. Endocrinology, 2022 Oct 11. PMID 36041019
  2. A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity. Sun S, et al. Funct Integr Genomics, 2021 Nov. PMID 34327622
  3. Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity. Landgraf K, et al. BMC Physiol, 2017 Mar 21. PMID 28327129, Free PMC Article
  4. The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Landgraf K, et al. Cell Rep, 2020 Oct 20. PMID 33086065
  5. A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism. Zhao Y, et al. Funct Integr Genomics, 2022 Aug. PMID 35290539

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables diacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables monoacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipase, hormone-sensitive a
Names
hormone-sensitive lipase
NP_001303654.1
XP_005159552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316725.1 → NP_001303654.1  lipase, hormone-sensitive a

    Status: VALIDATED

    Source sequence(s)
    BX005424
    UniProtKB/TrEMBL
    A0A8M1P847, A3KPJ7
    Related
    ENSDARP00000119692.1, ENSDART00000142614.2
    Conserved Domains (3) summary
    COG0657
    Location:351 → 682
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:6 → 318
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    pfam07859
    Location:351 → 658
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    10794042..10829598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159495.5 → XP_005159552.1  lipase, hormone-sensitive a isoform X1

    See identical proteins and their annotated locations for XP_005159552.1

    UniProtKB/TrEMBL
    A0A8M1P847, A3KPJ7
    Conserved Domains (3) summary
    COG0657
    Location:351 → 682
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:6 → 318
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    pfam07859
    Location:351 → 658
    Abhydrolase_3; alpha/beta hydrolase fold

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105121.1: Suppressed sequence

    Description
    NM_001105121.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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