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snx17 sorting nexin 17 [ Danio rerio (zebrafish) ]

Gene ID: 568263, updated on 28-Oct-2024

Summary

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Official Symbol
snx17provided by ZNC
Official Full Name
sorting nexin 17provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9475
See related
Ensembl:ENSDARG00000091418 AllianceGenome:ZFIN:ZDB-GENE-030131-9475
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb67g03; wu:fb67g09; wu:fc27g08; wu:fj81d04; si:ch211-101l18.2
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to act upstream of or within protein transport and signal transduction. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be active in early endosome. Is expressed in brain; eye; liver; and pancreas. Orthologous to human SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See snx17 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19436189..19511631, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19536604..19612057, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-278j3.3 Neighboring gene zinc finger protein 513a Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. Yong X, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34462354, Free PMC Article
  2. SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1. Yin W, et al. Cell Regen, 2012. PMID 25408867, Free PMC Article
  3. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
  4. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
  5. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045157.3 → NP_001038622.2  sorting nexin-17

    See identical proteins and their annotated locations for NP_001038622.2

    Status: PROVISIONAL

    Source sequence(s)
    BC162993
    UniProtKB/TrEMBL
    A0A0R4ITX6
    Related
    ENSDARP00000137695.1, ENSDART00000168521.2
    Conserved Domains (3) summary
    cd06885
    Location:2 → 105
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13337
    Location:268 → 388
    FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
    cl00155
    Location:115 → 185
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    19436189..19511631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294624.3 → XP_009292899.1  sorting nexin-17 isoform X1

    See identical proteins and their annotated locations for XP_009292899.1

    UniProtKB/Swiss-Prot
    B3DI45, Q5RID7
    Related
    ENSDARP00000040190.4, ENSDART00000040191.6
    Conserved Domains (3) summary
    cd06885
    Location:2 → 105
    PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
    cd13337
    Location:268 → 388
    FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
    cl00155
    Location:115 → 185
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RID7.1 GenPept UniProtKB/Swiss-Prot:Q5RID7

Gene LinkOut

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