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Extl3 exostosin-like glycosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56819, updated on 2-Nov-2024

Summary

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Symbol
Extl3provided by RGD
Full Name
exostosin-like glycosyltransferase 3provided by RGD
Primary source
RGD:62065
See related
EnsemblRapid:ENSRNOG00000013581 AllianceGenome:RGD:62065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Regr
Summary
Predicted to enable glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; magnesium ion binding activity; and protein-hormone receptor activity. Involved in positive regulation of cell growth. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 145.2), Muscle (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Extl3 in Genome Data Viewer
Location:
15p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43469293..43559760, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39294033..39384086, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48420419..48465171, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene high mobility group nucleosomal binding domain 4, pseudogene 7 Neighboring gene integrator complex subunit 9 Neighboring gene uncharacterized LOC134482133 Neighboring gene H/ACA ribonucleoprotein complex subunit 3-like Neighboring gene frizzled class receptor 3 Neighboring gene F-box protein 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Localization of Reg receptor in rat fundic mucosa. Kazumori H, et al. J Lab Clin Med, 2002 Feb. PMID 11919548
  2. Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. Oud MM, et al. Am J Hum Genet, 2017 Feb 2. PMID 28132690, Free PMC Article
  3. Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. Bluth MH, et al. World J Gastroenterol, 2006 Jul 28. PMID 16874863, Free PMC Article
  4. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. Kobayashi S, et al. J Biol Chem, 2000 Apr 14. PMID 10753861
  5. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. Volpi S, et al. J Exp Med, 2017 Mar 6. PMID 28148688, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.
    Title: Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor.
  2. localization in fundic mucosa
    Title: Localization of Reg receptor in rat fundic mucosa.
  3. Acute pancreatitis results in increased tissue reg I protein levels in the pancreas, as well as a threefold induction of reg I receptor. Induction of reg I and its receptor may be important for recovery from acute pancreatitis.
    Title: Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response to wounding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of detection of glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exostosin-like 3
Names
Reg receptor
exostoses (multiple)-like 3
exostoses-like 3
exostosin-like 3-like
NP_064482.1
XP_006252268.1
XP_038949546.1
XP_038949547.1
XP_038949548.1
XP_038949550.1
XP_038949551.1
XP_063130666.1
XP_063130667.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431349.1 → NP_001418278.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  2. NM_001431350.1 → NP_001418279.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  3. NM_001431351.1 → NP_001418280.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  4. NM_001431352.1 → NP_001418281.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  5. NM_001431353.1 → NP_001418282.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  6. NM_001431354.1 → NP_001418283.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  7. NM_001431355.1 → NP_001418284.1  exostosin-like 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7F308, Q9JMA8

  8. NM_020097.3 → NP_064482.1  exostosin-like 3

    See identical proteins and their annotated locations for NP_064482.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2K6F4, F7F308, Q9JMA8
    Related
    ENSRNOP00000073791.3, ENSRNOT00000077197.3
    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    43469293..43559760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093619.2 → XP_038949547.1  exostosin-like 3 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

  2. XM_039093622.2 → XP_038949550.1  exostosin-like 3 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

  3. XM_039093618.2 → XP_038949546.1  exostosin-like 3 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

  4. XM_039093623.2 → XP_038949551.1  exostosin-like 3 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

  5. XM_063274597.1 → XP_063130667.1  exostosin-like 3 isoform X1

  6. XM_039093620.2 → XP_038949548.1  exostosin-like 3 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain

  7. XM_063274596.1 → XP_063130666.1  exostosin-like 3 isoform X1

  8. XM_006252206.5 → XP_006252268.1  exostosin-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006252268.1

    UniProtKB/TrEMBL
    A0A0G2K6F4, F7F308, Q9JMA8
    Conserved Domains (3) summary
    COG1196
    Location:86 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam03016
    Location:190 → 500
    Exostosin; Exostosin family
    pfam09258
    Location:663 → 900
    Glyco_transf_64; Glycosyl transferase family 64 domain
Nucleotide Protein Strain
Heading Accession and Version

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