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agbl2 AGBL carboxypeptidase 2 [ Danio rerio (zebrafish) ]

Gene ID: 568152, updated on 18-Sep-2024

Summary

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Official Symbol
agbl2provided by ZNC
Official Full Name
AGBL carboxypeptidase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070719-6
See related
Ensembl:ENSDARG00000079983 AllianceGenome:ZFIN:ZDB-GENE-070719-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zte25; zgc:165648
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Predicted to act upstream of or within proteolysis. Predicted to be located in centriole; ciliary basal body; and cytosol. Is expressed in brain; otic vesicle; pronephros; and sensory system. Orthologous to human AGBL2 (AGBL carboxypeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See agbl2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (28596989..28638138, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (28153787..28194935, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 15 member 5 Neighboring gene PKc_like domain-containing protein Neighboring gene transmembrane protein 17 Neighboring gene formin binding protein 4 Neighboring gene leucine rich repeat containing 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development. Lyons PJ, et al. J Biol Chem, 2013 Oct 18. PMID 24022483, Free PMC Article
  2. Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Maimouni S, et al. Oncotarget, 2019 Feb 26. PMID 30899431, Free PMC Article
  3. Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Pathak N, et al. Mol Biol Cell, 2014 Jun 15. PMID 24743595, Free PMC Article
  4. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC165648

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein side chain deglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytosolic carboxypeptidase 2
Names
ATP/GTP binding protein-like 2
CCP2
protein deglutamylase CCP2
testis-expressed protein 25
zebrafish testis-expressed 25
NP_001307077.1
XP_017209580.1
XP_068073502.1
XP_068073503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320148.1 → NP_001307077.1  cytosolic carboxypeptidase 2

    Status: VALIDATED

    Source sequence(s)
    CR376836
    UniProtKB/TrEMBL
    A0A0R4IYD6, A0A8M1P7K9
    Related
    ENSDARP00000140657.2, ENSDART00000157493.2
    Conserved Domains (1) summary
    cd06907
    Location:344 → 604
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    28596989..28638138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354091.3 → XP_017209580.1  cytosolic carboxypeptidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z500

  2. XM_068217402.1 → XP_068073503.1  cytosolic carboxypeptidase 2 isoform X3

    Related
    ENSDARP00000116922.1, ENSDART00000138918.3

  3. XM_068217401.1 → XP_068073502.1  cytosolic carboxypeptidase 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099247.1: Suppressed sequence

    Description
    NM_001099247.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H8T7.1 GenPept UniProtKB/Swiss-Prot:A6H8T7

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