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lpar2b lysophosphatidic acid receptor 2b [ Danio rerio (zebrafish) ]

Gene ID: 567956, updated on 18-Sep-2024

Summary

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Official Symbol
lpar2bprovided by ZNC
Official Full Name
lysophosphatidic acid receptor 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-051120-99
See related
Ensembl:ENSDARG00000042561 AllianceGenome:ZFIN:ZDB-GENE-051120-99
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123246
Summary
Enables lysophosphatidic acid receptor activity. Acts upstream of or within angiogenesis and posterior lateral line development. Predicted to be located in cell surface; endosome; and membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in axis; posterior lateral line neuromast; posterior lateral line primordium; and yolk syncytial layer. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See lpar2b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (59191945..59216197, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (58415065..58439317, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene wu:fk65c09 Neighboring gene calmodulin-regulated spectrin-associated protein 3 Neighboring gene A kinase (PRKA) anchor protein 8-like Neighboring gene multivesicular body subunit 12A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis. Lin KH, et al. Sci Rep, 2016 May 31. PMID 27244685, Free PMC Article
  2. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Nakanaga K, et al. J Biochem, 2014 Apr. PMID 24451492
  3. Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish. Wang X, et al. Front Mol Neurosci, 2018. PMID 29479307, Free PMC Article
  4. Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish. Frisca F, et al. Sci Rep, 2016 Nov 24. PMID 27883058, Free PMC Article
  5. Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. Yukiura H, et al. J Biol Chem, 2011 Dec 23. PMID 21971049, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation.
    Title: Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC123246

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within posterior lateral line development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320133.1 → NP_001307062.1  lysophosphatidic acid receptor 2b

    Status: VALIDATED

    Source sequence(s)
    CABZ01118680, CABZ01118681, CABZ01118682, CABZ01118684
    UniProtKB/TrEMBL
    A0A8M2BIF4, F1Q734
    Related
    ENSDARP00000062425.5, ENSDART00000062426.6
    Conserved Domains (1) summary
    cd15342
    Location:29 → 300
    7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    59191945..59216197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475649.2 → XP_021331324.1  lysophosphatidic acid receptor 2b isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q1Z5
    Conserved Domains (1) summary
    cd15342
    Location:29 → 300
    7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_068220552.1 → XP_068076653.1  lysophosphatidic acid receptor 2b isoform X1

  3. XM_005171058.5 → XP_005171115.1  lysophosphatidic acid receptor 2b isoform X1

    See identical proteins and their annotated locations for XP_005171115.1

    UniProtKB/TrEMBL
    A0A8M2BIF4, F1Q734
    Conserved Domains (1) summary
    cd15342
    Location:29 → 300
    7tmA_LPAR2_Edg4; lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_068220558.1 → XP_068076659.1  lysophosphatidic acid receptor 2b isoform X2

  5. XM_068220546.1 → XP_068076647.1  lysophosphatidic acid receptor 2b isoform X1

  6. XM_068220540.1 → XP_068076641.1  lysophosphatidic acid receptor 2b isoform X1

RNA

  1. XR_011011357.1 RNA Sequence

  2. XR_011011356.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037694.1: Suppressed sequence

    Description
    NM_001037694.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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