maptb microtubule-associated protein tau b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: maptbprovided by ZNC
Official Full Name: microtubule-associated protein tau bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081027-2
See related: Ensembl:ENSDARG00000087616 AllianceGenome:ZFIN:ZDB-GENE-081027-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization and neuron projection development. Predicted to be located in cytoplasm and microtubule. Predicted to be active in neuron projection. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (22158021..22216455, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (22027473..22085882, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_068218902.1 → XP_068075003.1 microtubule-associated protein tau isoform X5
XM_068218901.1 → XP_068075002.1 microtubule-associated protein tau isoform X4
XM_068218898.1 → XP_068074999.1 microtubule-associated protein tau isoform X2
XM_021473452.2 → XP_021329127.1 microtubule-associated protein tau isoform X6

UniProtKB/TrEMBL

A0A8M9PDF7

Conserved Domains (2) summary

pfam00418
Location:619 → 648

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

cl26464
Location:266 → 581

Atrophin-1; Atrophin-1 family
XM_068218896.1 → XP_068074997.1 microtubule-associated protein tau isoform X1
XM_068218899.1 → XP_068075000.1 microtubule-associated protein tau isoform X3

Related

ENSDARP00000106770.2, ENSDART00000130546.3
XM_068218897.1 → XP_068074998.1 microtubule-associated protein tau isoform X1