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Tulp2 TUB like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 56734, updated on 17-Aug-2024

Summary

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Official Symbol
Tulp2provided by MGI
Official Full Name
TUB like protein 2provided by MGI
Primary source
MGI:MGI:1861600
See related
Ensembl:ENSMUSG00000023467 AllianceGenome:MGI:1861600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdet
Summary
Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in protein localization to cilium. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in cilium. Is expressed in urogenital ridge. Orthologous to human TULP2 (TUB like protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 195.7) See more
Orthologs
human all
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Genomic context

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See Tulp2 in Genome Data Viewer
Location:
7 B3; 7 29.33 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45131450..45173070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45482026..45523646)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene ferritin light polypeptide 1 Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase Neighboring gene nucleobindin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene STARR-seq mESC enhancer starr_18846

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility. Oyama Y, et al. Reprod Med Biol, 2022 Jan-Dec. PMID 35619658, Free PMC Article
  2. TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid Differentiation and Male Fertility. Zheng M, et al. Front Cell Dev Biol, 2021. PMID 33763418, Free PMC Article
  3. The tubby family proteins. Mukhopadhyay S, et al. Genome Biol, 2011 Jun 28. PMID 21722349, Free PMC Article
  4. Identification and characterization of the developmentally regulated pattern of expression in the testis of a mouse gene exhibiting similarity to the family of phosphodiesterases. Vambutas V, et al. Biochim Biophys Acta, 1994 Mar 1. PMID 7509194
  5. Cell-specific expression of tubby gene family members (tub, Tulp1,2, and 3) in the retina. Ikeda S, et al. Invest Ophthalmol Vis Sci, 1999 Oct. PMID 10509669

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC107290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoric diester hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubby-related protein 2
Names
protein P4-6
testis specific phosphodiesterase
tubby-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045555.2 → NP_001039020.1  tubby-related protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001039020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. The resulting isoform (2) is the same length but has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK054304, AK077200, BY087813
    Consensus CDS
    CCDS39953.1
    UniProtKB/Swiss-Prot
    P46686, Q3TTV1, Q5FW93, Q8C5R7, Q8C5R9, Q9R1I8
    Related
    ENSMUSP00000103391.2, ENSMUST00000107762.10
    Conserved Domains (2) summary
    pfam01167
    Location:315 → 555
    Tub; Tub family
    pfam16322
    Location:39 → 264
    Tub_N; Tubby N-terminal

  2. NM_001290996.2 → NP_001277925.1  tubby-related protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 2. The resulting isoform (3) contains an alternate internal segment and is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AC151602, AK054304
    Consensus CDS
    CCDS71961.1
    UniProtKB/TrEMBL
    A0A1B0GRN6
    Related
    ENSMUSP00000147596.2, ENSMUST00000210813.2
    Conserved Domains (2) summary
    pfam01167
    Location:203 → 450
    Tub; Tub family
    pfam16322
    Location:6 → 152
    Tub_N; Tubby N-terminal

  3. NM_001290998.2 → NP_001277927.1  tubby-related protein 2 isoform 4

    See identical proteins and their annotated locations for NP_001277927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC151602, BC089545
    Consensus CDS
    CCDS80720.1
    UniProtKB/Swiss-Prot
    P46686
    Related
    ENSMUSP00000082438.6, ENSMUST00000085331.14
    Conserved Domains (1) summary
    pfam01167
    Location:191 → 431
    Tub; Tub family

  4. NM_001290999.2 → NP_001277928.1  tubby-related protein 2 isoform 5

    See identical proteins and their annotated locations for NP_001277928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC151602, AK161165
    Consensus CDS
    CCDS71960.1
    UniProtKB/Swiss-Prot
    P46686
    Related
    ENSMUSP00000103388.2, ENSMUST00000107759.10
    Conserved Domains (1) summary
    pfam01167
    Location:203 → 445
    Tub; Tub family

  5. NM_008807.3 → NP_032833.2  tubby-related protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) is the same length but has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC151602, BB617192, BC048740, BY087813
    Consensus CDS
    CCDS39954.1
    UniProtKB/Swiss-Prot
    P46686
    Related
    ENSMUSP00000024233.7, ENSMUST00000024233.15
    Conserved Domains (2) summary
    pfam01167
    Location:315 → 555
    Tub; Tub family
    pfam16322
    Location:39 → 264
    Tub_N; Tubby N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45131450..45173070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541020.2 → XP_006541083.1  tubby-related protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006541083.1

    Conserved Domains (2) summary
    pfam01167
    Location:259 → 508
    Tub; Tub family
    pfam16322
    Location:1 → 147
    Tub_N; Tubby N-terminal

  2. XM_036153278.1 → XP_036009171.1  tubby-related protein 2 isoform X6

    Conserved Domains (2) summary
    pfam01167
    Location:259 → 508
    Tub; Tub family
    pfam16322
    Location:1 → 147
    Tub_N; Tubby N-terminal

  3. XM_030242817.2 → XP_030098677.1  tubby-related protein 2 isoform X7

    UniProtKB/TrEMBL
    D3Z0R4
    Conserved Domains (1) summary
    pfam01167
    Location:203 → 452
    Tub; Tub family

  4. XM_006541017.4 → XP_006541080.2  tubby-related protein 2 isoform X2

    Conserved Domains (3) summary
    pfam01167
    Location:315 → 564
    Tub; Tub family
    pfam06658
    Location:17 → 53
    DUF1168; Protein of unknown function (DUF1168)
    pfam16322
    Location:39 → 199
    Tub_N; Tubby N-terminal

  5. XM_006541016.3 → XP_006541079.2  tubby-related protein 2 isoform X1

    Conserved Domains (3) summary
    pfam01167
    Location:315 → 564
    Tub; Tub family
    pfam06658
    Location:17 → 53
    DUF1168; Protein of unknown function (DUF1168)
    pfam16322
    Location:39 → 199
    Tub_N; Tubby N-terminal

  6. XM_006541019.4 → XP_006541082.2  tubby-related protein 2 isoform X4

    Conserved Domains (3) summary
    pfam01167
    Location:298 → 547
    Tub; Tub family
    pfam06658
    Location:17 → 53
    DUF1168; Protein of unknown function (DUF1168)
    pfam16322
    Location:39 → 199
    Tub_N; Tubby N-terminal

  7. XM_006541018.4 → XP_006541081.2  tubby-related protein 2 isoform X3

    Conserved Domains (2) summary
    pfam01167
    Location:304 → 553
    Tub; Tub family
    pfam16322
    Location:28 → 188
    Tub_N; Tubby N-terminal

  8. XM_006541022.2 → XP_006541085.1  tubby-related protein 2 isoform X7

    See identical proteins and their annotated locations for XP_006541085.1

    UniProtKB/TrEMBL
    D3Z0R4
    Conserved Domains (1) summary
    pfam01167
    Location:203 → 452
    Tub; Tub family

  9. XM_030242816.2 → XP_030098676.1  tubby-related protein 2 isoform X5

    Conserved Domains (2) summary
    pfam01167
    Location:304 → 546
    Tub; Tub family
    pfam16322
    Location:28 → 188
    Tub_N; Tubby N-terminal

  10. XM_030242818.1 → XP_030098678.1  tubby-related protein 2 isoform X8

    Conserved Domains (1) summary
    pfam01167
    Location:203 → 445
    Tub; Tub family

  11. XM_036153279.1 → XP_036009172.1  tubby-related protein 2 isoform X7

    UniProtKB/TrEMBL
    D3Z0R4
    Related
    ENSMUSP00000103387.4, ENSMUST00000107758.10
    Conserved Domains (1) summary
    pfam01167
    Location:203 → 452
    Tub; Tub family

  12. XM_006541025.4 → XP_006541088.1  tubby-related protein 2 isoform X9

    UniProtKB/Swiss-Prot
    P46686
    Related
    ENSMUSP00000147710.2, ENSMUST00000210868.2
    Conserved Domains (1) summary
    pfam01167
    Location:203 → 445
    Tub; Tub family

  13. XM_030242819.1 → XP_030098679.1  tubby-related protein 2 isoform X8

    Conserved Domains (1) summary
    pfam01167
    Location:203 → 445
    Tub; Tub family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46686.3 GenPept UniProtKB/Swiss-Prot:P46686

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