U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

git2b G protein-coupled receptor kinase interacting ArfGAP 2b [ Danio rerio (zebrafish) ]

Gene ID: 567190, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
git2bprovided by ZNC
Official Full Name
G protein-coupled receptor kinase interacting ArfGAP 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-2192
See related
Ensembl:ENSDARG00000042791 AllianceGenome:ZFIN:ZDB-GENE-070112-2192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
git2; zgc:158416
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See git2b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (40283980..40317479)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (40362743..40396293)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496607 Neighboring gene CXADR like membrane protein Neighboring gene GRAM domain containing 1Ba Neighboring gene glycolipid transfer protein b Neighboring gene trace amine associated receptor 20b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development. Yu JA, et al. Dev Biol, 2011 Jan 15. PMID 21034731, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ARF GTPase-activating protein GIT2b
Names
G protein-coupled receptor kinase interactor 2b
G protein-coupled receptor kinase-interactor 2
tyrosine-phosphorylated protein CAT-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080188.2 → NP_001073657.2  ARF GTPase-activating protein GIT2b isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL953903
    UniProtKB/TrEMBL
    A1L1V5
    Related
    ENSDARP00000099372.3, ENSDART00000113582.5
    Conserved Domains (7) summary
    smart00105
    Location:5 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:123 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:626 → 730
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam14203
    Location:246 → 284
    TTRAP; Putative tranposon-transfer assisting protein
    pfam16559
    Location:425 → 479
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  2. NM_001362634.1 → NP_001349563.1  ARF GTPase-activating protein GIT2b isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL953903
    UniProtKB/TrEMBL
    A0A8M2B1P7, A1L1V5
    Conserved Domains (6) summary
    smart00105
    Location:5 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:123 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:596 → 700
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:425 → 479
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    40283980..40317479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_011016940.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394797.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50098..83574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.