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pde3a phosphodiesterase 3A, cGMP-inhibited [ Danio rerio (zebrafish) ]

Gene ID: 567051, updated on 2-Nov-2024

Summary

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Official Symbol
pde3aprovided by ZNC
Official Full Name
phosphodiesterase 3A, cGMP-inhibitedprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-23
See related
Ensembl:ENSDARG00000004227 AllianceGenome:ZFIN:ZDB-GENE-041210-23
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-48h7.2
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in oocyte and oocyte stage V. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pde3a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (2746740..2923348, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (2816629..2937995, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene B cell receptor associated protein 29 Neighboring gene solute carrier organic anion transporter family, member 1C1 Neighboring gene AE binding protein 2 Neighboring gene pleckstrin homology domain containing, family A member 5 Neighboring gene uncharacterized LOC137491498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells. Xu J, et al. Sci Rep, 2018 Oct 22. PMID 30349097, Free PMC Article
  2. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Pang Y, et al. Gen Comp Endocrinol, 2018 Sep 1. PMID 29574150
  3. Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Potok ME, et al. Cell, 2013 May 9. PMID 23663776, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
XP_009298269.1
XP_009298270.1
XP_009298271.1
XP_009298272.1
XP_068076815.1
XP_068076816.1
XP_068076817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    2746740..2923348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068220714.1 → XP_068076815.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X5

  2. XM_068220716.1 → XP_068076817.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X6

  3. XM_009299996.4 → XP_009298271.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X3

    UniProtKB/TrEMBL
    A0A8M3B1G7, F6P4K3
    Related
    ENSDARP00000119110.2, ENSDART00000133843.3
    Conserved Domains (1) summary
    pfam00233
    Location:681 → 940
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_009299995.4 → XP_009298270.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X2

    UniProtKB/TrEMBL
    A0A8M3ARD3
    Conserved Domains (1) summary
    pfam00233
    Location:687 → 946
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_009299997.4 → XP_009298272.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X4

    UniProtKB/TrEMBL
    A0A8M3AYI3
    Conserved Domains (1) summary
    pfam00233
    Location:670 → 929
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. XM_009299994.4 → XP_009298269.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1

    UniProtKB/TrEMBL
    A0A8M3B8Q1
    Conserved Domains (1) summary
    pfam00233
    Location:688 → 947
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. XM_068220715.1 → XP_068076816.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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