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pde4d phosphodiesterase 4D, cAMP-specific [ Danio rerio (zebrafish) ]

Gene ID: 566998, updated on 17-Sep-2024

Summary

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Official Symbol
pde4dprovided by ZNC
Official Full Name
phosphodiesterase 4D, cAMP-specificprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-16
See related
Ensembl:ENSDARG00000032761 AllianceGenome:ZFIN:ZDB-GENE-081105-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-190g11.2
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in signal transduction. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in brain; female organism; and head. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pde4d in Genome Data Viewer
Location:
chromosome: 8
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (16772066..17052840)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (16782565..17009649)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene excision repair cross-complementation group 8 Neighboring gene ELOVL fatty acid elongase 7a Neighboring gene si:dkey-190g11.3 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene polo-like kinase 2b (Drosophila)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Lundegaard PR, et al. Chem Biol, 2015 Oct 22. PMID 26388333, Free PMC Article
  2. Different mutations in PDE4D associated with developmental disorders with mirror phenotypes. Lindstrand A, et al. J Med Genet, 2014 Jan. PMID 24203977
  3. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Yang H, et al. Dev Biol, 2015 Aug 15. PMID 26004360, Free PMC Article
  4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; 3',5'-cyclic-AMP phosphodiesterase 4D
Names
cAMP-specific phosphodiesterase 4D
XP_009302145.1
XP_021327706.1
XP_021329820.1
XP_021329821.1
XP_021334068.1
XP_068075327.1
XP_068075328.1
XP_068075329.1
XP_068075330.1
XP_068075332.1
XP_068075333.1
XP_068079221.1
XP_068079222.1
XP_068079223.1
XP_068079224.1
XP_068079225.1
XP_068079226.1
XP_068079227.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    16772066..17052840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223121.1 → XP_068079222.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  2. XM_068223120.1 → XP_068079221.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  3. XM_068223124.1 → XP_068079225.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

  4. XM_068223123.1 → XP_068079224.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

  5. XM_009303870.4 → XP_009302145.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

    UniProtKB/TrEMBL
    A0A8M3B1W5
    Conserved Domains (1) summary
    pfam00233
    Location:397 → 634
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. XM_068223125.1 → XP_068079226.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

  7. XM_068223122.1 → XP_068079223.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  8. XM_068223126.1 → XP_068079227.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

  9. XM_021478393.2 → XP_021334068.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X9

    UniProtKB/TrEMBL
    A0A8M9Q3T2
    Related
    ENSDARP00000013442.8, ENSDART00000018934.9
    Conserved Domains (1) summary
    pfam00233
    Location:331 → 568
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394716.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    139388..165060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021472031.2 → XP_021327706.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X10

    UniProtKB/TrEMBL
    A0A8M9PF62

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395270.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    6626..322674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219227.1 → XP_068075328.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  2. XM_068219226.1 → XP_068075327.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  3. XM_068219231.1 → XP_068075332.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

  4. XM_068219229.1 → XP_068075330.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

  5. XM_021474145.2 → XP_021329820.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

    UniProtKB/TrEMBL
    A0A8M3B1W5
    Conserved Domains (1) summary
    pfam00233
    Location:397 → 634
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. XM_068219228.1 → XP_068075329.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  7. XM_068219232.1 → XP_068075333.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

  8. XM_021474146.2 → XP_021329821.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X9

    UniProtKB/TrEMBL
    A0A8M9Q3T2
    Conserved Domains (1) summary
    pfam00233
    Location:331 → 568
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
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