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afap1l1a actin filament associated protein 1-like 1a [ Danio rerio (zebrafish) ]

Gene ID: 566757, updated on 2-Nov-2024

Summary

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Official Symbol
afap1l1aprovided by ZNC
Official Full Name
actin filament associated protein 1-like 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-76
See related
Ensembl:ENSDARG00000089162 AllianceGenome:ZFIN:ZDB-GENE-050913-76
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
afap1l1; zgc:114084
Summary
Predicted to be located in several cellular components, including actin cytoskeleton; anchoring junction; and cell projection. Predicted to be active in cytosol. Is expressed in hindbrain. Orthologous to human AFAP1L1 (actin filament associated protein 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See afap1l1a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34562426..34633960, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (34222112..34293646, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene actin binding LIM protein family, member 3 Neighboring gene SH3 domain and tetratricopeptide repeats 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. Meyen D, et al. Elife, 2015 Apr 15. PMID 25875301, Free PMC Article
  2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
  3. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114084

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin filament-associated protein 1-like 1
Names
AFAP1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030213.1 → NP_001025384.1  actin filament-associated protein 1-like 1

    See identical proteins and their annotated locations for NP_001025384.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097145
    UniProtKB/Swiss-Prot
    Q4V8Y7
    Related
    ENSDARP00000111322.2, ENSDART00000128869.4
    Conserved Domains (3) summary
    cd13306
    Location:204 → 310
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:403 → 503
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:220 → 308
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    34562426..34633960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213234.1 → XP_068069335.1  actin filament-associated protein 1-like 1 isoform X3

    Related
    ENSDARP00000145106.1, ENSDART00000179977.1

  2. XM_009291126.4 → XP_009289401.1  actin filament-associated protein 1-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AS30
    Conserved Domains (3) summary
    cd13306
    Location:217 → 323
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:416 → 516
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:233 → 321
    PH; PH domain

  3. XM_005173256.5 → XP_005173313.1  actin filament-associated protein 1-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8RU06, A0A8M2BKK9
    Related
    ENSDARP00000152800.1, ENSDART00000191608.1
    Conserved Domains (3) summary
    cd13306
    Location:217 → 323
    PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
    cd13307
    Location:416 → 516
    PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:233 → 321
    PH; PH domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394919.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    65719..134781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395317.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    65713..136825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8Y7.1 GenPept UniProtKB/Swiss-Prot:Q4V8Y7

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