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LINC00470 long intergenic non-protein coding RNA 470 [ Homo sapiens (human) ]

Gene ID: 56651, updated on 10-Oct-2023

Summary

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Official Symbol
LINC00470provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 470provided by HGNC
Primary source
HGNC:HGNC:1225
See related
AllianceGenome:HGNC:1225
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf2
Expression
Biased expression in testis (RPKM 1.4), placenta (RPKM 1.0) and 1 other tissue See more
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Genomic context

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Location:
18p11.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (1268311..1359629, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (1422813..1514125, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (1268312..1359630, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371953 Neighboring gene solute carrier family 25 member 3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5202 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:1208318-1209041 Neighboring gene MPRA-validated peak3040 silencer Neighboring gene RN7SK pseudogene 72 Neighboring gene ATPase family AAA domain containing 1 pseudogene Neighboring gene uncharacterized LOC105371954 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:1369016-1369234 Neighboring gene uncharacterized LOC105371960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. Wu C, et al. J Cell Mol Med, 2020 Oct. PMID 32916774, Free PMC Article
  2. LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma. Huang W, et al. Hum Cell, 2020 Jan. PMID 31612313
  3. LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression. Huang T, et al. Cell Death Dis, 2021 Apr 19. PMID 33875645, Free PMC Article
  4. Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells. Lai X, et al. J Cell Mol Med, 2021 May. PMID 33749070, Free PMC Article
  5. LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells. Yan J, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31711642

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.
    Title: Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.
  2. LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
    Title: LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression.
  3. Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells.
    Title: Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells.
  4. LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma.
    Title: LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma.
  5. LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma.
    Title: LncRNA LINC00470 promotes proliferation through association with NF45/NF90 complex in hepatocellular carcinoma.
  6. LINC00470 is upregulated in the gastric cancer tissues and promotes GC cell proliferation, migration and invasion.LINC00470 associated with PTEN mRNA and suppressed its stability through interaction with the N(6)-methyladenosine (m(6)A) writer METTL3.
    Title: LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_023925.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AF295725, AF295730, AK057505, AP000829

  2. NR_023926.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses an alternate splice site, compared to variant 1.
    Source sequence(s)
    AF295725, AF295726, AF295730, AK057505, AP000829

  3. NR_023927.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks internal exons, compared to variant 1.
    Source sequence(s)
    AF295730, AK057505, AP000829

  4. NR_110327.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks internal exons, compared to variant 1.
    Source sequence(s)
    AP000829, AP005119

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    1268311..1359629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    1422813..1514125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031416.2: Suppressed sequence

    Description
    NM_031416.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZP3.1 GenPept UniProtKB/Swiss-Prot:Q9BZP3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous