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mapk6 mitogen-activated protein kinase 6 [ Danio rerio (zebrafish) ]

Gene ID: 565830, updated on 2-Nov-2024

Summary

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Official Symbol
mapk6provided by ZNC
Official Full Name
mitogen-activated protein kinase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-050420-7
See related
Ensembl:ENSDARG00000032103 AllianceGenome:ZFIN:ZDB-GENE-050420-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
erk3; p97mapk; si:ch211-235f12.1
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; otic vesicle; and pectoral fin. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mapk6 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (39171856..39188417, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (39190846..39219557, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene BCL2 like 10 Neighboring gene uncharacterized LOC137488228 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene tropomodulin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Neurotoxicological effects induced by up-regulation of miR-137 following triclosan exposure to zebrafish (Danio rerio). Liu J, et al. Aquat Toxicol, 2019 Jan. PMID 30496951
  2. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Shi X, et al. Toxicol Sci, 2010 Jun. PMID 20200220
  3. Characterization and expression patterns of the MAPK family in zebrafish. Krens SF, et al. Gene Expr Patterns, 2006 Oct. PMID 16774848
  4. Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish. Wu Q, et al. Sci Total Environ, 2019 Nov 25. PMID 31374495
  5. Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Yin J, et al. Environ Toxicol Pharmacol, 2017 Dec. PMID 29102874

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 6
Names
extracellular signal-regulated kinase 3
NP_001039017.1
XP_017207438.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045552.1 → NP_001039017.1  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_001039017.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ360074
    UniProtKB/TrEMBL
    A0A0R4ID10, F6P883, Q0H1F2
    Related
    ENSDARP00000034206.7, ENSDART00000029549.9
    Conserved Domains (2) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    39171856..39188417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351949.3 → XP_017207438.1  mitogen-activated protein kinase 6 isoform X1

    UniProtKB/TrEMBL
    A0A0R4ID10, F6P883, Q0H1F2
    Related
    ENSDARP00000130447.1, ENSDART00000162983.3
    Conserved Domains (2) summary
    cd07854
    Location:14 → 355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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