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c5 complement component 5 [ Danio rerio (zebrafish) ]

Gene ID: 565774, updated on 12-Sep-2024

Summary

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Official Symbol
c5provided by ZNC
Official Full Name
complement component 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-120510-2
See related
Ensembl:ENSDARG00000021004 AllianceGenome:ZFIN:ZDB-GENE-120510-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (63458185..63509606, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (62764793..62816231, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene RAB14, member RAS oncogene family Neighboring gene centriolin Neighboring gene PR domain containing 12b Neighboring gene uncharacterized LOC137495528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The evolutionary analysis of complement component C5 and the gene co-expression network and putative interaction between C5a and C5a anaphylatoxin receptor (C5AR/CD88) in human and two Cyprinid fish. Li L, et al. Dev Comp Immunol, 2021 Mar. PMID 33290783
  2. Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. Buchan KD, et al. J Cell Sci, 2021 Mar 4. PMID 33589501
  3. iTRAQ analysis of gill proteins from the zebrafish (Danio rerio) infected with Aeromonas hydrophila. Lü A, et al. Fish Shellfish Immunol, 2014 Jan. PMID 24269520
  4. Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. Sehring I, et al. Elife, 2022 Jun 24. PMID 35748539, Free PMC Article
  5. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Houseright RA, et al. Sci Rep, 2020 Sep 24. PMID 32973200, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    63458185..63509606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919191.9 → XP_001919226.4  complement C5

    UniProtKB/TrEMBL
    A0A8M1QL13, E7FCV2
    Related
    ENSDARP00000088095.4, ENSDART00000097325.6
    Conserved Domains (8) summary
    cd00017
    Location:687 → 756
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam00207
    Location:786 → 873
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:124 → 218
    A2M_N; MG2 domain
    pfam07677
    Location:1438 → 1528
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1064 → 1322
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:472 → 615
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1546 → 1698
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl08267
    Location:1005 → 1320
    ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
Nucleotide Protein Strain
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