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ctsf cathepsin F [ Danio rerio (zebrafish) ]

Gene ID: 565588, updated on 28-Oct-2024

Summary

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Official Symbol
ctsfprovided by ZNC
Official Full Name
cathepsin Fprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9831
See related
Ensembl:ENSDARG00000063095 AllianceGenome:ZFIN:ZDB-GENE-030131-9831
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb420; sb:cb420; zgc:153093
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in mesoderm; nervous system; neural tube; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See ctsf in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7140997..7164646)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6834549..6858237)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch73-43g23.1 Neighboring gene tRNA phosphotransferase 1 Neighboring gene storkhead box 2b Neighboring gene trafficking protein particle complex subunit 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker. Che R, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25181651
  2. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Tingaud-Sequeira A, et al. Gene, 2007 Jan 15. PMID 17027199
  3. Zebrafish Chromosome 14 Gene Differential Expression in the fmr1 (h u2787) Model of Fragile X Syndrome. Barthelson K, et al. Front Genet, 2021. PMID 34135935, Free PMC Article
  4. Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Vihtelic TS, et al. Mol Vis, 2005 Dec 13. PMID 16379021
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153093

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cathepsin F
NP_001071036.1
XP_005157210.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077568.1 → NP_001071036.1  cathepsin F precursor

    See identical proteins and their annotated locations for NP_001071036.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124243
    UniProtKB/TrEMBL
    Q08CH0
    Related
    ENSDARP00000112297.1, ENSDART00000129898.3
    Conserved Domains (4) summary
    PTZ00203
    Location:143 → 472
    PTZ00203; cathepsin L protease; Provisional
    smart00043
    Location:34 → 144
    CY; Cystatin-like domain
    smart00848
    Location:175 → 231
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:262 → 471
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    7140997..7164646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157153.5 → XP_005157210.1  cathepsin F isoform X1

    UniProtKB/TrEMBL
    A0A8M9QKM5, F1RE14
    Related
    ENSDARP00000132041.1, ENSDART00000170994.2
    Conserved Domains (3) summary
    smart00043
    Location:34 → 144
    CY; Cystatin-like domain
    smart00848
    Location:175 → 231
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:262 → 471
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein Strain
Heading Accession and Version

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