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pja2 praja ring finger ubiquitin ligase 2 [ Danio rerio (zebrafish) ]

Gene ID: 565118, updated on 2-Nov-2024

Summary

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Official Symbol
pja2provided by ZNC
Official Full Name
praja ring finger ubiquitin ligase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-337
See related
Ensembl:ENSDARG00000100296 AllianceGenome:ZFIN:ZDB-GENE-060526-337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-79c1.2
Summary
Predicted to enable metal ion binding activity. Is expressed in brain; head mesenchyme; post-vent vasculature; trunk vasculature; and yolk syncytial layer. Orthologous to several human genes including PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pja2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (57210237..57234124)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (56539988..56563907)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2A, member 1 Neighboring gene uncharacterized LOC103911128 Neighboring gene uncharacterized LOC101886669 Neighboring gene fer (fps/fes related) tyrosine kinase Neighboring gene uncharacterized LOC137495640 Neighboring gene ATPase H+ transporting V1 subunit G1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Shin J, et al. Genes Cancer, 2017 Jul. PMID 28966725, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Praja-2
Names
praja ring finger 2
NP_001098586.2
XP_009300150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105116.2 → NP_001098586.2  E3 ubiquitin-protein ligase Praja-2

    Status: VALIDATED

    Source sequence(s)
    CT009691, FP928982
    UniProtKB/TrEMBL
    A0A0R4IPD9, A0A8M1NFW1
    Related
    ENSDARP00000138079.1, ENSDART00000167660.2
    Conserved Domains (1) summary
    pfam13639
    Location:587 → 628
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    57210237..57234124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301875.3 → XP_009300150.1  E3 ubiquitin-protein ligase Praja-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AZZ7
    Conserved Domains (1) summary
    pfam13639
    Location:588 → 629
    zf-RING_2; Ring finger domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394616.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    17625..41506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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