U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

trip12 thyroid hormone receptor interactor 12 [ Danio rerio (zebrafish) ]

Gene ID: 564866, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
trip12provided by ZNC
Official Full Name
thyroid hormone receptor interactor 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-041111-262
See related
Ensembl:ENSDARG00000061397 AllianceGenome:ZFIN:ZDB-GENE-041111-262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7149446; si:ch211-272f3.4
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including chromatin remodeling; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Is expressed in myotome. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See trip12 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (41232713..41310976)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (41242518..41320784)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene F-box protein 36a Neighboring gene ventricular zone expressed PH domain-containing 1 Neighboring gene wu:fb55f04 Neighboring gene pentraxin 3, long a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterochromatin boundary formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase TRIP12
Names
HECT-type E3 ubiquitin transferase TRIP12
TR-interacting protein 12
thyroid receptor-interacting protein 12
NP_001334597.1
XP_001919036.4
XP_005159283.1
XP_005159284.1
XP_005159285.1
XP_005159286.1
XP_005159287.1
XP_021323347.1
XP_068070901.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347668.1 → NP_001334597.1  E3 ubiquitin-protein ligase TRIP12

    Status: VALIDATED

    Source sequence(s)
    BX255887, CU928079
    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M1P4D4, F1Q529
    Related
    ENSDARP00000082000.6, ENSDART00000087566.6
    Conserved Domains (4) summary
    cd00078
    Location:1651 → 2051
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:800 → 865
    WWE; WWE domain
    cl25709
    Location:480 → 671
    Arm_3; Atypical Arm repeat
    cl28033
    Location:59 → 440
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    41232713..41310976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159226.5 → XP_005159283.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_005159283.1

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B655
    Conserved Domains (3) summary
    smart00119
    Location:1711 → 2090
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1693 → 2094
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:842 → 907
    WWE; WWE domain

  2. XM_005159229.5 → XP_005159286.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B5U3
    Conserved Domains (3) summary
    smart00119
    Location:1711 → 2089
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1693 → 2093
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:842 → 907
    WWE; WWE domain

  3. XM_005159230.5 → XP_005159287.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    See identical proteins and their annotated locations for XP_005159287.1

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B5R0
    Conserved Domains (3) summary
    smart00119
    Location:1669 → 2048
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1651 → 2052
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:800 → 865
    WWE; WWE domain

  4. XM_021467672.2 → XP_021323347.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M1P4D4, F1Q529
    Conserved Domains (4) summary
    cd00078
    Location:1651 → 2051
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:800 → 865
    WWE; WWE domain
    cl25709
    Location:480 → 671
    Arm_3; Atypical Arm repeat
    cl28033
    Location:59 → 440
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  5. XM_005159228.4 → XP_005159285.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_005159285.1

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B655
    Conserved Domains (3) summary
    smart00119
    Location:1711 → 2090
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1693 → 2094
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:842 → 907
    WWE; WWE domain

  6. XM_068214800.1 → XP_068070901.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  7. XM_001919001.7 → XP_001919036.4  E3 ubiquitin-protein ligase TRIP12 isoform X3

    See identical proteins and their annotated locations for XP_001919036.4

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B5R0
    Conserved Domains (3) summary
    smart00119
    Location:1669 → 2048
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1651 → 2052
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:800 → 865
    WWE; WWE domain

  8. XM_005159227.5 → XP_005159284.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_005159284.1

    UniProtKB/Swiss-Prot
    A3KPN5, F1RCR6
    UniProtKB/TrEMBL
    A0A8M2B655
    Conserved Domains (3) summary
    smart00119
    Location:1711 → 2090
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1693 → 2094
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:842 → 907
    WWE; WWE domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395046.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    51534..112954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1RCR6.1 GenPept UniProtKB/Swiss-Prot:F1RCR6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.