acap2a ArfGAP with coiled-coil, ankyrin repeat and PH domains 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acap2aprovided by ZNC
Official Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081104-34
See related: Ensembl:ENSDARG00000056478 AllianceGenome:ZFIN:ZDB-GENE-081104-34
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-168b3.1
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (5887630..5926562)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (5975751..6012333)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

5887630..5926562

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163249.5 → XP_005163306.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M2BAD9, B8JLA1

Related

ENSDARP00000121563.2, ENSDART00000147831.3

Conserved Domains (7) summary

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

cd00204
Location:658 → 776

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:273 → 369

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:273 → 365

PH; PH domain

pfam01412
Location:402 → 520

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:660 → 754

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:657 → 686

ANK; ANK repeat [structural motif]
XM_009297237.4 → XP_009295512.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8M3AVV3

Related

ENSDARP00000156920.1, ENSDART00000188119.1

Conserved Domains (7) summary

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

cd00204
Location:657 → 775

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:273 → 369

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:273 → 365

PH; PH domain

pfam01412
Location:402 → 520

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:659 → 753

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:656 → 685

ANK; ANK repeat [structural motif]
XM_068213489.1 → XP_068069590.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3
XM_068213490.1 → XP_068069591.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3