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Rgs19 regulator of G-protein signaling 19 [ Mus musculus (house mouse) ]

Gene ID: 56470, updated on 2-Nov-2024

Summary

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Official Symbol
Rgs19provided by MGI
Official Full Name
regulator of G-protein signaling 19provided by MGI
Primary source
MGI:MGI:1915153
See related
Ensembl:ENSMUSG00000002458 AllianceGenome:MGI:1915153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAIP; 2610042F04Rik
Summary
Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in brush border and clathrin-coated vesicle. Is expressed in embryo; forelimb bud; palatal shelf epithelium; and primary palate epithelium. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 53.3), thymus adult (RPKM 37.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Rgs19 in Genome Data Viewer
Location:
2 H4; 2 103.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181330212..181336330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181688419..181694537, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 18 Neighboring gene transcription elongation factor A (SII), 2 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif) Neighboring gene STARR-positive B cell enhancer mm9_chr2:181441345-181441645 Neighboring gene opioid receptor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Critical role of Rgs19 in mouse embryonic stem cell proliferation and differentiation. Ji YR, et al. Differentiation, 2015 Jan-Feb. PMID 25766428
  2. Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19). Sangphech N, et al. Immunobiology, 2014 Sep. PMID 24775271, Free PMC Article
  3. Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE. Sohn WJ, et al. Mech Dev, 2012 Sep-Dec. PMID 22841956
  4. RGS19 enhances cell proliferation through its C-terminal PDZ motif. Tso PH, et al. Cell Signal, 2010 Nov. PMID 20599498
  5. Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. Xie GX, et al. J Mol Biol, 2003 Jan 24. PMID 12507475

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation.
    Title: Critical role of Rgs19 in mouse embryonic stem cell proliferation and differentiation.
  2. Notch signaling positively regulates phosphorylation of Akt, possibly via phosphorylation of RGS19
    Title: Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19).
  3. RGS19 and its partner Galpha-inhibiting activity polypeptide 3 (GNAI3) are involved in zVAD-, but not TNF-, induced cell death.
    Title: Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells.
  4. level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3, or RGS19; or had been treated with pertussis toxin, were similar to controls
    Title: Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.
  5. Rgs19 plays important roles in palatal fusion.
    Title: Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE.
  6. Regulator of G protein signaling 19 enhances cell proliferation through binding to GAIP-interacting protein C-terminus.
    Title: RGS19 enhances cell proliferation through its C-terminal PDZ motif.
  7. RGS19 influenced cardiac development and had negative effects on heart function.
    Title: Effects of regulator of G protein signaling 19 (RGS19) on heart development and function.
  8. Results suggest a complex role for RGS19 in regulating the ability of Wnt3a to signal to the level of beta-catenin and gene transcription.
    Title: RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o).
  9. RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference
    Title: N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 protein in regulating ORL1 receptor signaling.
  10. gene structure and transcription regulation
    Title: Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 19
Names
G-alpha interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291205.1 → NP_001278134.1  regulator of G-protein signaling 19 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK042531, AL844529, BY540555
    Consensus CDS
    CCDS71223.1
    UniProtKB/TrEMBL
    B7ZCT1
    Related
    ENSMUSP00000104408.2, ENSMUST00000108778.8
    Conserved Domains (1) summary
    cd08745
    Location:114 → 231
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

  2. NM_001291206.1 → NP_001278135.1  regulator of G-protein signaling 19 isoform b

    See identical proteins and their annotated locations for NP_001278135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK042531, AL845173, BG085760, BY540555
    Consensus CDS
    CCDS17220.1
    UniProtKB/Swiss-Prot
    Q99L50, Q9CX84
    UniProtKB/TrEMBL
    Q78NN4, Q8CGT5
    Related
    ENSMUSP00000104406.2, ENSMUST00000108776.8
    Conserved Domains (1) summary
    cl02565
    Location:87 → 204
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. NM_001291207.1 → NP_001278136.1  regulator of G-protein signaling 19 isoform c

    See identical proteins and their annotated locations for NP_001278136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks an internal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AK019401, AK042531, AL845173, BU694737, BY540555
    Consensus CDS
    CCDS71222.1
    UniProtKB/TrEMBL
    Q8BFU4, Q8CGT5
    Related
    ENSMUSP00000104403.2, ENSMUST00000108772.8
    Conserved Domains (1) summary
    cl02565
    Location:65 → 182
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. NM_001291208.1 → NP_001278137.1  regulator of G-protein signaling 19 isoform c

    See identical proteins and their annotated locations for NP_001278137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and lacks an internal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
    Source sequence(s)
    AK042531, AL845173, BG085760, BY540555
    Consensus CDS
    CCDS71222.1
    UniProtKB/TrEMBL
    Q8BFU4, Q8CGT5
    Related
    ENSMUSP00000104402.2, ENSMUST00000108771.2
    Conserved Domains (1) summary
    cl02565
    Location:65 → 182
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. NM_001291209.1 → NP_001278138.1  regulator of G-protein signaling 19 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains alternate 5' and 3' terminal exons, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon and contains an alternate 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK019401, AK042531, AL845173, BY540555, BY549770, CF751080
    UniProtKB/TrEMBL
    B7ZCT0
    Related
    ENSMUSP00000104400.2, ENSMUST00000108769.8
    Conserved Domains (1) summary
    cl02565
    Location:52 → 157
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  6. NM_001291210.1 → NP_001278139.1  regulator of G-protein signaling 19 isoform e

    See identical proteins and their annotated locations for NP_001278139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks two internal exons, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK019401, AK042531, AL845173, BY540555
    UniProtKB/Swiss-Prot
    Q9CX84
    UniProtKB/TrEMBL
    Q78NN4
    Conserved Domains (1) summary
    cl02565
    Location:1 → 110
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  7. NM_026446.4 → NP_080722.1  regulator of G-protein signaling 19 isoform b

    See identical proteins and their annotated locations for NP_080722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AK019401, AK042531, AL845173, BY540555
    Consensus CDS
    CCDS17220.1
    UniProtKB/Swiss-Prot
    Q99L50, Q9CX84
    UniProtKB/TrEMBL
    Q78NN4, Q8CGT5
    Related
    ENSMUSP00000002532.3, ENSMUST00000002532.9
    Conserved Domains (1) summary
    cl02565
    Location:87 → 204
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181330212..181336330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251895.1 → XP_030107755.1  regulator of G-protein signaling 19 isoform X2

  2. XM_030251897.2 → XP_030107757.1  regulator of G-protein signaling 19 isoform X4

    UniProtKB/TrEMBL
    B7ZCT0
    Conserved Domains (1) summary
    cl02565
    Location:30 → 135
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_030251896.1 → XP_030107756.1  regulator of G-protein signaling 19 isoform X3

    UniProtKB/TrEMBL
    B7ZCT0
    Conserved Domains (1) summary
    cl02565
    Location:52 → 157
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_030251894.1 → XP_030107754.1  regulator of G-protein signaling 19 isoform X1

    UniProtKB/Swiss-Prot
    Q99L50, Q9CX84
    UniProtKB/TrEMBL
    Q78NN4, Q8CGT5
    Conserved Domains (1) summary
    cl02565
    Location:87 → 204
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CX84.1 GenPept UniProtKB/Swiss-Prot:Q9CX84

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