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kcnn2 potassium calcium-activated channel subfamily N member 2 [ Danio rerio (zebrafish) ]

Gene ID: 564698, updated on 2-Nov-2024

Summary

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Official Symbol
kcnn2provided by ZNC
Official Full Name
potassium calcium-activated channel subfamily N member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-091116-41
See related
Ensembl:ENSDARG00000014939 AllianceGenome:ZFIN:ZDB-GENE-091116-41
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-76p7.5
Summary
Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including brain; heart; neural rod; neural tube; and tail bud. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See kcnn2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (17591867..17675828)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (17634111..17717162)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SNF2 related chromatin remodeling ATPase with DExD box 1b Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene uncharacterized LOC103911737 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene microRNA 218b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line. Carpaneto Freixas AE, et al. J Neurosci, 2021 Jan 6. PMID 33203744, Free PMC Article
  2. Atrium-specific ion channels in the zebrafish-A role of I(KACh) in atrial repolarization. Skarsfeldt MA, et al. Acta Physiol (Oxf), 2018 Jul. PMID 29412518
  3. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small conductance calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
small conductance calcium-activated potassium channel protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    17591867..17675828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_688028.8 → XP_693120.4  small conductance calcium-activated potassium channel protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8N7UVC3
    Related
    ENSDARP00000122596.1, ENSDART00000141221.2
    Conserved Domains (3) summary
    smart01053
    Location:511 → 589
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:223 → 330
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:416 → 497
    Ion_trans_2; Ion channel

  2. XM_005155638.5 → XP_005155695.1  small conductance calcium-activated potassium channel protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2K1
    Conserved Domains (3) summary
    pfam02888
    Location:511 → 564
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:223 → 330
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:416 → 497
    Ion_trans_2; Ion channel

  3. XM_068223939.1 → XP_068080040.1  small conductance calcium-activated potassium channel protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version

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