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reps1 RALBP1 associated Eps domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 564535, updated on 12-Sep-2024

Summary

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Official Symbol
reps1provided by ZNC
Official Full Name
RALBP1 associated Eps domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9536
See related
Ensembl:ENSDARG00000002877 AllianceGenome:ZFIN:ZDB-GENE-030131-9536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj85c06; si:dkey-217m5.1
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to act upstream of or within receptor-mediated endocytosis. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See reps1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (39222814..39258515)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (39319585..39355633)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC108180313 Neighboring gene cytochrome P450, family 39, subfamily A, polypeptide 1 Neighboring gene clusterin Neighboring gene scavenger receptor class A, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ralBP1-associated Eps domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045056.2 → NP_001038521.1  ralBP1-associated Eps domain-containing protein 1

    Status: PROVISIONAL

    Source sequence(s)
    AL845306, AL929058
    UniProtKB/TrEMBL
    A0A8M1N9W4, Q5VSI7
    Related
    ENSDARP00000117870.1, ENSDART00000132132.4
    Conserved Domains (3) summary
    smart00027
    Location:275 → 366
    EH; Eps15 homology domain
    cd00052
    Location:286 → 352
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl08302
    Location:14 → 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    39222814..39258515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160831.5 → XP_005160888.1  ralBP1-associated Eps domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7S1
    Conserved Domains (3) summary
    smart00027
    Location:275 → 366
    EH; Eps15 homology domain
    cd00052
    Location:286 → 352
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl08302
    Location:14 → 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_005160832.5 → XP_005160889.1  ralBP1-associated Eps domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B7T2
    Conserved Domains (3) summary
    smart00027
    Location:275 → 366
    EH; Eps15 homology domain
    cd00052
    Location:286 → 352
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl08302
    Location:14 → 81
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_021468478.2 → XP_021324153.1  ralBP1-associated Eps domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PBU8
    Conserved Domains (3) summary
    smart00027
    Location:275 → 366
    EH; Eps15 homology domain
    cl25836
    Location:129 → 260
    Retinal; Retinal protein
    cl27812
    Location:10 → 85
    EF-hand_4; Cytoskeletal-regulatory complex EF hand
Nucleotide Protein Strain
Heading Accession and Version

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