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st6galnac1.1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 564336, updated on 2-Nov-2024

Summary

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Official Symbol
st6galnac1.1provided by ZNC
Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-160
See related
Ensembl:ENSDARG00000043814 AllianceGenome:ZFIN:ZDB-GENE-041014-160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siat3; st6GalNAc I; si:ch211-51n14.1
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in oligosaccharide biosynthetic process. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in brain; gill; integument; liver; and pleuroperitoneal region. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See st6galnac1.1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20678187..20685624)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (20556210..20563750)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide Neighboring gene matrix-remodelling associated 7 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, tandem duplicate 2 Neighboring gene CASK interacting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  2. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1
Names
alpha 2,6-sialyltransferase ST6GalNAc I
st6galnac1-r1
NP_001314970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328041.1 → NP_001314970.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.1

    Status: VALIDATED

    Source sequence(s)
    CR385044
    UniProtKB/TrEMBL
    A0A8M9QEC7, Q5P990
    Related
    ENSDARP00000115490.2, ENSDART00000146762.3
    Conserved Domains (1) summary
    pfam00777
    Location:120 → 404
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    20678187..20685624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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