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usp43a ubiquitin specific peptidase 43a [ Danio rerio (zebrafish) ]

Gene ID: 563983, updated on 2-Nov-2024

Summary

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Official Symbol
usp43aprovided by ZNC
Official Full Name
ubiquitin specific peptidase 43aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100211-1
See related
Ensembl:ENSDARG00000103494 AllianceGenome:ZFIN:ZDB-GENE-100211-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-57c18.1
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination and proteolysis. Orthologous to human USP43 (ubiquitin specific peptidase 43). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See usp43a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (19477888..19665198, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (23008457..23193924, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene growth factor receptor-bound protein 2a Neighboring gene melanin-concentrating hormone receptor 1a Neighboring gene cilia and flagella associated protein 52 Neighboring gene uncharacterized LOC137490206 Neighboring gene syntaxin 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 43a
Names
usp43
NP_001082871.1
XP_009300632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089402.1 → NP_001082871.1  ubiquitin carboxyl-terminal hydrolase 43a

    See identical proteins and their annotated locations for NP_001082871.1

    Status: PROVISIONAL

    Source sequence(s)
    BX908749
    UniProtKB/TrEMBL
    A3KQN0
    Related
    ENSDARP00000136694.2, ENSDART00000159749.2
    Conserved Domains (3) summary
    COG5560
    Location:76 → 717
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:549 → 714
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:115 → 297
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    19477888..19665198 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302357.4 → XP_009300632.1  ubiquitin carboxyl-terminal hydrolase 43a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B3E4
    Conserved Domains (3) summary
    COG5560
    Location:76 → 746
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:578 → 743
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:115 → 315
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394638.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    148259..309368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395253.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    155253..325956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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