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zgc:136930 zgc:136930 [ Danio rerio (zebrafish) ]

Gene ID: 563946, updated on 14-Nov-2024

Summary

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Official Symbol
zgc:136930provided by ZNC
Official Full Name
zgc:136930provided by ZNC
Primary source
ZFIN:ZDB-GENE-060312-16
See related
Ensembl:ENSDARG00000055192 AllianceGenome:ZFIN:ZDB-GENE-060312-16
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj22d03; wu:fj22d03
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; ectodermal dysplasia 4; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT78 (keratin 78); KRT80 (keratin 80); and KRT81 (keratin 81). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See zgc:136930 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32780124..32790888)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32796920..32807669)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 9a Neighboring gene kelch-like family member 18 Neighboring gene beaded filament structural protein 2, phakinin Neighboring gene uncharacterized LOC110438072 Neighboring gene pre-mRNA processing factor 4Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genes coding for intermediate filament proteins closely related to the hagfish "thread keratins (TK)" alpha and gamma also exist in lamprey, teleosts and amphibians. Schaffeld M, et al. Exp Cell Res, 2006 May 15. PMID 16494865
  2. UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY, et al. Animals (Basel), 2020 Jun 25. PMID 32630437, Free PMC Article
  3. Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. Cokus SJ, et al. G3 (Bethesda), 2019 Oct 7. PMID 31431477, Free PMC Article
  4. Stable isotope labeling in zebrafish allows in vivo monitoring of cardiac morphogenesis. Konzer A, et al. Mol Cell Proteomics, 2013 Jun. PMID 23412571, Free PMC Article
  5. Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Rabinowitz JS, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096348, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC136930

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC563946
Names
thread keratin gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039819.2 → NP_001034908.1  uncharacterized protein LOC563946

    See identical proteins and their annotated locations for NP_001034908.1

    Status: VALIDATED

    Source sequence(s)
    CR855308
    UniProtKB/TrEMBL
    Q29R96
    Related
    ENSDARP00000076687.4, ENSDART00000082250.5
    Conserved Domains (1) summary
    pfam00038
    Location:34 → 353
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    32780124..32790888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480887.2 → XP_021336562.1  uncharacterized protein LOC563946 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PYS6
    Conserved Domains (1) summary
    pfam00038
    Location:120 → 439
    Filament; Intermediate filament protein
Nucleotide Protein
Heading Accession and Version

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