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antxr1c ANTXR cell adhesion molecule 1c [ Danio rerio (zebrafish) ]

Gene ID: 563907, updated on 2-Nov-2024

Summary

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Official Symbol
antxr1cprovided by ZNC
Official Full Name
ANTXR cell adhesion molecule 1cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090514-5
See related
Ensembl:ENSDARG00000063612 AllianceGenome:ZFIN:ZDB-GENE-090514-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
antxr1
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in cranial vasculature; spinal cord; tail bud; and trunk vasculature. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to several human genes including ANTXRL (ANTXR like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See antxr1c in Genome Data Viewer
Location:
chromosome: 12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (2677278..2740719)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (2642524..2705622)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene interphotoreceptor retinoid-binding protein like Neighboring gene retinol binding protein 3 Neighboring gene ubiquitin domain containing 1b Neighboring gene MMS19 homolog, cytosolic iron-sulfur assembly component Neighboring gene zinc finger DHHC-type palmitoyltransferase 16b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Anthrax toxin receptor 2a controls mitotic spindle positioning. Castanon I, et al. Nat Cell Biol, 2013 Jan. PMID 23201782
  2. Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos. Wong KS, et al. Dev Dyn, 2009 Jul. PMID 19504456
  3. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article
  4. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. Gomez G, et al. PLoS One, 2012. PMID 22438865, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anthrax toxin receptor 1
Names
anthrax toxin receptor 1c
tem8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    2677278..2740719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_687270.8 → XP_692362.2  anthrax toxin receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7TBB2, E7F2W8
    Related
    ENSDARP00000087545.4, ENSDART00000093113.6
    Conserved Domains (3) summary
    cd01474
    Location:37 → 218
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:391 → 483
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:220 → 314
    Anth_Ig; Anthrax receptor extracellular domain

  2. XM_009306392.4 → XP_009304667.1  anthrax toxin receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3BDY9
    Related
    ENSDARP00000155513.1, ENSDART00000185909.1
    Conserved Domains (3) summary
    cd01474
    Location:37 → 218
    vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
    pfam05586
    Location:391 → 483
    Ant_C; Anthrax receptor C-terminus region
    pfam05587
    Location:220 → 314
    Anth_Ig; Anthrax receptor extracellular domain
Nucleotide Protein
Heading Accession and Version

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