pomt2 protein-O-mannosyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pomt2provided by ZNC
Official Full Name: protein-O-mannosyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1002
See related: Ensembl:ENSDARG00000055027 AllianceGenome:ZFIN:ZDB-GENE-070112-1002
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zPOMT2; im:7153045; zgc:158749
Summary: Enables dolichyl-phosphate-mannose-protein mannosyltransferase activity. Acts upstream of or within protein O-linked mannosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; fin bud; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly and muscular dystrophy (multiple). Orthologous to human POMT2 (protein O-mannosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31696441..31712062, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31679478..31695066, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein O-mannosylation is necessary for normal embryonic development.
Title: Protein O-mannosylation is necessary for normal embryonic development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein O-linked mannosylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-mannosyl-transferase 2

NP_001038498.1

EC 2.4.1.109

XP_005158842.1

EC 2.4.1.109

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045033.1 → NP_001038498.1 protein O-mannosyl-transferase 2

Status: PROVISIONAL

Source sequence(s)

DQ826749

UniProtKB/Swiss-Prot

F1Q8R9

Related

ENSDARP00000071774.4, ENSDART00000077307.5

Conserved Domains (4) summary

smart00472
Location:479 → 528

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

COG1928
Location:68 → 756

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

pfam02366
Location:76 → 316

PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase

pfam16192
Location:545 → 754

PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

31696441..31712062 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158785.4 → XP_005158842.1 protein O-mannosyl-transferase 2 isoform X1

UniProtKB/Swiss-Prot

A1L2B0, E0CZK0, F1Q8R9, Q0PIP2

Conserved Domains (1) summary

COG1928
Location:68 → 756

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]