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tctn2 tectonic family member 2 [ Danio rerio (zebrafish) ]

Gene ID: 563835, updated on 2-Nov-2024

Summary

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Official Symbol
tctn2provided by ZNC
Official Full Name
tectonic family member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-751
See related
Ensembl:ENSDARG00000035633 AllianceGenome:ZFIN:ZDB-GENE-030131-751
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb44f11; wu:fb44f11; si:ch211-89f7.3
Summary
Acts upstream of or within determination of left/right symmetry. Predicted to be part of MKS complex. Human ortholog(s) of this gene implicated in Joubert syndrome 24 and Meckel syndrome 8. Orthologous to human TCTN2 (tectonic family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tctn2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (13394640..13426890)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (12894407..12926543)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 3b Neighboring gene chemokine (C-C motif) ligand 19a, tandem duplicate 1 Neighboring gene chemokine (C-C motif) ligand 19a, tandem duplicate 2 Neighboring gene SEC14-like lipid binding 8 Neighboring gene novel protein similar to human and mouse cyclin M4 (CNNM4) Neighboring gene uncharacterized LOC101885304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Liu C, et al. Genome Med, 2018 May 30. PMID 29843777, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MKS complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tectonic-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    13394640..13426890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_687198.9 → XP_692290.5  tectonic-2

    UniProtKB/TrEMBL
    A0A8N7UV03, F1R5E2
    Related
    ENSDARP00000051668.7, ENSDART00000051669.8
    Conserved Domains (1) summary
    pfam07773
    Location:176 → 440
    DUF1619; Protein of unknown function (DUF1619)
Nucleotide Protein Strain
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