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skp2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 563708, updated on 2-Nov-2024

Summary

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Official Symbol
skp2provided by ZNC
Official Full Name
S-phase kinase-associated protein 2, E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-158
See related
Ensembl:ENSDARG00000004937 AllianceGenome:ZFIN:ZDB-GENE-030219-158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb933; id:ibd5121; wu:fa10b08; wu:fj97b11; zgc:162950
Summary
Predicted to enable kinase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and regulation of cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; intermediate cell mass of mesoderm; nervous system; and ventral mesoderm. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See skp2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22347120..22357987, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22310484..22321351, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4b Neighboring gene NAD kinase 2, mitochondrial Neighboring gene uncharacterized LOC137488808 Neighboring gene uncharacterized LOC137488809 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment. Zheng H, et al. J Environ Sci (China), 2011. PMID 21793410
  2. Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis. Uribe RA, et al. Dev Biol, 2012 Nov 15. PMID 22981606, Free PMC Article
  3. MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis. Shen LJ, et al. PLoS One, 2013. PMID 23554972, Free PMC Article
  4. RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. Shen L, et al. BMC Cancer, 2015 Dec 16. PMID 26674644, Free PMC Article
  5. Genome-wide analysis of facial skeletal regionalization in zebrafish. Askary A, et al. Development, 2017 Aug 15. PMID 28705894, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-phase kinase-associated protein 2
Names
S-phase kinase-associated protein 2 (p45)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082837.2 → NP_001076306.1  S-phase kinase-associated protein 2

    See identical proteins and their annotated locations for NP_001076306.1

    Status: VALIDATED

    Source sequence(s)
    BC134165, BX470072, CT679586
    UniProtKB/TrEMBL
    A0A8M1NBV0, A3KP53
    Related
    ENSDARP00000092527.3, ENSDART00000101751.5
    Conserved Domains (3) summary
    cd09293
    Location:173 → 324
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:151 → 173
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:88 → 133
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    22347120..22357987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161189.5 → XP_005161246.1  S-phase kinase-associated protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B860
    Conserved Domains (3) summary
    cd09293
    Location:190 → 341
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:168 → 190
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:105 → 150
    F-box-like; F-box-like

  2. XM_068215914.1 → XP_068072015.1  S-phase kinase-associated protein 2 isoform X2

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395349.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    487041..497908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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