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Tagln3 transgelin 3 [ Mus musculus (house mouse) ]

Gene ID: 56370, updated on 2-Nov-2024

Summary

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Official Symbol
Tagln3provided by MGI
Official Full Name
transgelin 3provided by MGI
Primary source
MGI:MGI:1926784
See related
Ensembl:ENSMUSG00000022658 AllianceGenome:MGI:1926784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Np25; 2700038H05Rik; 2900005O10Rik
Summary
Predicted to enable actin filament binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in central nervous system; gut; olfactory epithelium; peripheral nervous system; and retina. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 204.8), CNS E14 (RPKM 149.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Tagln3 in Genome Data Viewer
Location:
16 B5; 16 29.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45531591..45545271, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45711230..45724531, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence, BC016579 Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40919 Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene abhydrolase domain containing 10 Neighboring gene pleckstrin homology like domain, family B, member 2 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Petryshen TL, et al. Genetics, 2005 Dec. PMID 15998716, Free PMC Article
  2. Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. O'Neil SD, et al. Elife, 2021 Jul 16. PMID 34269176, Free PMC Article
  3. Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain. Ware M, et al. Neural Dev, 2016 Dec 7. PMID 27923395, Free PMC Article
  4. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Feng J, et al. Biol Reprod, 2008 Sep. PMID 18480465, Free PMC Article
  5. Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Heanue TA, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16632597, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
transgelin-3
Names
neuronal protein Np25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019754.3 → NP_062728.1  transgelin-3

    See identical proteins and their annotated locations for NP_062728.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055338
    Consensus CDS
    CCDS28200.1
    UniProtKB/Swiss-Prot
    Q9R1Q8
    Related
    ENSMUSP00000093762.5, ENSMUST00000096057.5
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21281
    Location:23 → 141
    CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45531591..45545271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939202.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1Q8.1 GenPept UniProtKB/Swiss-Prot:Q9R1Q8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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