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Sult1b1 sulfotransferase family 1B, member 1 [ Mus musculus (house mouse) ]

Gene ID: 56362, updated on 2-Nov-2024

Summary

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Official Symbol
Sult1b1provided by MGI
Official Full Name
sulfotransferase family 1B, member 1provided by MGI
Primary source
MGI:MGI:2136282
See related
Ensembl:ENSMUSG00000029269 AllianceGenome:MGI:2136282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST1B1; St2b2
Summary
Enables aryl sulfotransferase activity. Involved in sulfation and thyroid hormone metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SULT1B1 (sulfotransferase family 1B member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 7.1), colon adult (RPKM 1.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Sult1b1 in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87661186..87686054, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87513327..87538195, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B38 Neighboring gene STARR-seq mESC enhancer starr_13559 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A1 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A2 Neighboring gene STARR-seq mESC enhancer starr_13560 Neighboring gene sulfotransferase family 1D, member 1 Neighboring gene sulfotransferase family 1E, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes.
    Title: Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
  2. mSult1b1 is suggested as a major enzyme responsible for XA sulfation in jejunum
    Title: Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables aryl sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in ethanol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ethanol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in flavonoid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in flavonoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phenol-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sulfotransferase 1B1
Names
dopa/tyrosine sulfotransferase
sulfotransferase family cytosolic 1B member 1
NP_001343872.1
NP_001369766.1
NP_063931.1
XP_006535215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356943.1 → NP_001343872.1  sulfotransferase 1B1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC158917, AK087595
    Consensus CDS
    CCDS19391.1
    UniProtKB/Swiss-Prot
    Q8C301, Q9QWG7, Q9Z2T0
    Related
    ENSMUSP00000112679.2, ENSMUST00000117455.8
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 289
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001382837.1 → NP_001369766.1  sulfotransferase 1B1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC158917
    UniProtKB/Swiss-Prot
    Q8C301, Q9QWG7, Q9Z2T0
    Related
    ENSMUSP00000112844.2, ENSMUST00000120150.2
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 289
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_019878.4 → NP_063931.1  sulfotransferase 1B1

    See identical proteins and their annotated locations for NP_063931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC158917
    Consensus CDS
    CCDS19391.1
    UniProtKB/Swiss-Prot
    Q8C301, Q9QWG7, Q9Z2T0
    Related
    ENSMUSP00000031199.5, ENSMUST00000031199.11
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 289
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    87661186..87686054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535152.4 → XP_006535215.1  sulfotransferase 1B1 isoform X1

    See identical proteins and their annotated locations for XP_006535215.1

    UniProtKB/Swiss-Prot
    Q8C301, Q9QWG7, Q9Z2T0
    Conserved Domains (1) summary
    pfam00685
    Location:38 → 289
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWG7.2 GenPept UniProtKB/Swiss-Prot:Q9QWG7

Gene LinkOut

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Chemical Information
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