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inpp5b inositol polyphosphate-5-phosphatase B [ Danio rerio (zebrafish) ]

Gene ID: 563543, updated on 2-Nov-2024

Summary

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Official Symbol
inpp5bprovided by ZNC
Official Full Name
inositol polyphosphate-5-phosphatase Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110411-228
See related
Ensembl:ENSDARG00000103683 AllianceGenome:ZFIN:ZDB-GENE-110411-228
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-175f12.3
Summary
Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within several processes, including Kupffer's vesicle development; melanosome transport; and pronephric duct morphogenesis. Predicted to be located in early endosome membrane and phagocytic vesicle membrane. Predicted to be active in cytosol; membrane; and neuron projection. Orthologous to human INPP5B (inositol polyphosphate-5-phosphatase B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See inpp5b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4078458..4131337)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4281585..4327933)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC556653 Neighboring gene uncharacterized protein DDB_G0271670 Neighboring gene metal-regulatory transcription factor 1 Neighboring gene uncharacterized LOC100535213 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe. Luo N, et al. PLoS One, 2013. PMID 23805271, Free PMC Article
  2. Impaired neural development in a zebrafish model for Lowe syndrome. Ramirez IB, et al. Hum Mol Genet, 2012 Apr 15. PMID 22210625, Free PMC Article
  3. The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). Yang S, et al. Int J Biol Macromol, 2023 Jun 1. PMID 37001786
  4. Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Lin SJ, et al. Dev Genes Evol, 2017 Jun. PMID 28154937
  5. Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Shestopalov IA, et al. Nat Chem Biol, 2012 Jan 29. PMID 22286130, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within melanosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pronephric duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to epinephrine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type II inositol 1,4,5-trisphosphate 5-phosphatase
Names
inositol polyphosphate-5-phosphatase, 75kDa
XP_009290335.3
XP_017206940.1
XP_017206941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    4078458..4131337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292060.4 → XP_009290335.3  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQB1
    Related
    ENSDARP00000140577.2, ENSDART00000166241.2
    Conserved Domains (4) summary
    cd09093
    Location:253 → 545
    INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
    cd04380
    Location:680 → 892
    RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
    pfam14874
    Location:574 → 648
    PapD-like; Flagellar-associated PapD-like
    pfam16776
    Location:6 → 146
    INPP5B_PH; Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain

  2. XM_017351451.3 → XP_017206940.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z189

  3. XM_017351452.3 → XP_017206941.1  type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X3

    UniProtKB/TrEMBL
    A0A8M6YTK6
Nucleotide Protein Strain
Heading Accession and Version

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