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Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 [ Mus musculus (house mouse) ]

Gene ID: 56348, updated on 2-Nov-2024

Summary

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Official Symbol
Hsd17b12provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 12provided by MGI
Primary source
MGI:MGI:1926967
See related
Ensembl:ENSMUSG00000027195 AllianceGenome:MGI:1926967
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kik1; KIK-I; 2610510O05Rik
Summary
Enables collagen binding activity; fibronectin binding activity; and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 41.7), liver E18 (RPKM 29.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hsd17b12 in Genome Data Viewer
Location:
2 E1; 2 51.62 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93863042..93988254, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (94032697..94157909, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05169 Neighboring gene predicted gene 13889 Neighboring gene alkB homolog 3, opposite strand 1 Neighboring gene alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93850845-93851104 Neighboring gene STARR-seq mESC enhancer starr_05171 Neighboring gene STARR-seq mESC enhancer starr_05172 Neighboring gene STARR-positive B cell enhancer ABC_E511 Neighboring gene MIR670 host gene (non-protein coding) Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:94018945-94019238 Neighboring gene predicted gene, 39885 Neighboring gene microRNA 129-2 Neighboring gene microRNA 129b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diet, obesity, and hyperglycemia in LG/J and SM/J mice. Ehrich TH, et al. Obes Res, 2003 Nov. PMID 14627762
  2. The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility. Kemiläinen H, et al. Endocrinology, 2016 Oct. PMID 27490311
  3. Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase. Blanchard PG, et al. J Endocrinol, 2007 Aug. PMID 17641292
  4. Hydroxysteroid (17{beta}) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival. Rantakari P, et al. Endocrinology, 2010 Apr. PMID 20130115
  5. Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice. Heikelä H, et al. Am J Physiol Endocrinol Metab, 2020 Sep 1. PMID 32691632

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hydroxysteroid (17beta) dehydrogenase 12 is essential for metabolic homeostasis in adult mice.
    Title: Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice.
  2. important role in female fertility through its role in arachidonic acid metabolism
    Title: The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.
  3. Hsd17b12 is essential for mouse organogenesis and embryonic survival.
    Title: Hydroxysteroid (17{beta}) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables fibronectin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain 3-oxoacyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in estrogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid elongation, saturated fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation, saturated fatty acid ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid elongase complex IEA
Inferred from Electronic Annotation
more info
  
part_of fatty acid elongase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
very-long-chain 3-oxoacyl-CoA reductase
Names
17-beta-HSD 12
17-beta-hydroxysteroid dehydrogenase 12
3-ketoacyl-CoA reductase
KAR
estradiol 17-beta-dehydrogenase 12
keratoadhesin
keratonectin
steroid dehydrogenase
NP_062631.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019657.4 → NP_062631.1  very-long-chain 3-oxoacyl-CoA reductase

    See identical proteins and their annotated locations for NP_062631.1

    Status: PROVISIONAL

    Source sequence(s)
    AL772372, BX284932
    Consensus CDS
    CCDS16458.1
    UniProtKB/Swiss-Prot
    O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39
    UniProtKB/TrEMBL
    Q0VGQ1
    Related
    ENSMUSP00000028619.5, ENSMUST00000028619.5
    Conserved Domains (3) summary
    cd05356
    Location:50 → 288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    COG0300
    Location:46 → 305
    DltE; Short-chain dehydrogenase [General function prediction only]
    cl21454
    Location:4 → 83
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93863042..93988254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70503.1 GenPept UniProtKB/Swiss-Prot:O70503

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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