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CABP5 calcium binding protein 5 [ Homo sapiens (human) ]

Gene ID: 56344, updated on 5-Mar-2024

Summary

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Official Symbol
CABP5provided by HGNC
Official Full Name
calcium binding protein 5provided by HGNC
Primary source
HGNC:HGNC:13714
See related
Ensembl:ENSG00000105507 MIM:607315; AllianceGenome:HGNC:13714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CABP3
Summary
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in adrenal (RPKM 2.1), brain (RPKM 1.8) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See CABP5 in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48029383..48044079, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51021772..51037932, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48532640..48547336, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene binder of sperm protein homolog 1 Neighboring gene epididymal sperm binding protein 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:48522004-48523203 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48564610-48565203 Neighboring gene phospholipase A2 group IVC Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48565204-48565796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48565797-48566389 Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10871 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Haeseleer F, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785943
  2. Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum. Di Jeso B, et al. J Biol Chem, 2014 Apr 18. PMID 24599957, Free PMC Article
  3. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Sokal I, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11108966
  4. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. McCue HV, et al. Biochem Biophys Res Commun, 2009 Mar 20. PMID 19338761, Free PMC Article
  5. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. Haeseleer F, et al. J Biol Chem, 2000 Jan 14. PMID 10625670, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the faster migrating Tg adduct C primarily engages the CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A primarily engages ERp72.
    Title: Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-binding protein 5
Names
calcium-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019855.5 → NP_062829.1  calcium-binding protein 5

    See identical proteins and their annotated locations for NP_062829.1

    Status: REVIEWED

    Source sequence(s)
    AA318398, AC010330, AC010458, AF169159, BU734136
    Consensus CDS
    CCDS12709.1
    UniProtKB/Swiss-Prot
    A0AUY4, Q9NP86
    Related
    ENSP00000293255.1, ENST00000293255.3
    Conserved Domains (1) summary
    cl25352
    Location:25 → 171
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48029383..48044079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51021772..51037932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016367.1: Suppressed sequence

    Description
    NM_016367.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NP86.1 GenPept UniProtKB/Swiss-Prot:Q9NP86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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