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ankhd1 ankyrin repeat and KH domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 563327, updated on 2-Nov-2024

Summary

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Official Symbol
ankhd1provided by ZNC
Official Full Name
ankyrin repeat and KH domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-090421-1
See related
Ensembl:ENSDARG00000077860 AllianceGenome:ZFIN:ZDB-GENE-090421-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable RNA binding activity. Acts upstream of or within heart contraction. Predicted to be active in cytoplasm. Orthologous to several human genes including ANKHD1 (ankyrin repeat and KH domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ankhd1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26408016..26483237, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26371321..26446769, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene zgc:110540 Neighboring gene transfer RNA serine (anticodon GCU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Friedrichs F, et al. Genome Res, 2009 Mar. PMID 19064678, Free PMC Article
  2. Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Murphy PJ, et al. Cell, 2018 Feb 22. PMID 29456083
  3. Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. Yuan JM, et al. J Virol, 2015 Jan. PMID 25355883, Free PMC Article
  4. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and KH domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199768.1 → NP_001186697.1  ankyrin repeat and KH domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    CR354383
    UniProtKB/TrEMBL
    A0A0R4IUB2, A0A8M1NVJ9
    Related
    ENSDARP00000138826.2, ENSDART00000169072.2
    Conserved Domains (7) summary
    smart00248
    Location:1048 → 1076
    ANK; ankyrin repeats
    cd00105
    Location:1709 → 1771
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:289 → 415
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:266 → 355
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:364 → 415
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:396 → 425
    ANK; ANK repeat [structural motif]
    cl09111
    Location:811 → 849
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    26408016..26483237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295484.4 → XP_009293759.1  ankyrin repeat and KH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3ALL9
    Conserved Domains (7) summary
    smart00248
    Location:1059 → 1087
    ANK; ankyrin repeats
    cd00105
    Location:1720 → 1782
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:278 → 404
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:255 → 344
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:353 → 404
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:385 → 414
    ANK; ANK repeat [structural motif]
    cl09111
    Location:800 → 838
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  2. XM_009295483.4 → XP_009293758.1  ankyrin repeat and KH domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AU09
    Conserved Domains (7) summary
    smart00248
    Location:1064 → 1092
    ANK; ankyrin repeats
    cd00105
    Location:1725 → 1787
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:283 → 409
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:260 → 349
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:358 → 409
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:390 → 419
    ANK; ANK repeat [structural motif]
    cl09111
    Location:805 → 843
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  3. XM_005161355.5 → XP_005161412.1  ankyrin repeat and KH domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B8J4
    Conserved Domains (7) summary
    smart00248
    Location:1070 → 1098
    ANK; ankyrin repeats
    cd00105
    Location:1731 → 1793
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:289 → 415
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:266 → 355
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:364 → 415
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:396 → 425
    ANK; ANK repeat [structural motif]
    cl09111
    Location:811 → 849
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  4. XM_009295482.4 → XP_009293757.1  ankyrin repeat and KH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AWZ5, E9QEX9
    Related
    ENSDARP00000121740.1, ENSDART00000147947.2
    Conserved Domains (7) summary
    smart00248
    Location:1075 → 1103
    ANK; ankyrin repeats
    cd00105
    Location:1736 → 1798
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:294 → 420
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:271 → 360
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:369 → 420
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:401 → 430
    ANK; ANK repeat [structural motif]
    cl09111
    Location:816 → 854
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
Nucleotide Protein Strain
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