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Amotl2 angiomotin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 56332, updated on 2-Nov-2024

Summary

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Official Symbol
Amotl2provided by MGI
Official Full Name
angiomotin-like 2provided by MGI
Primary source
MGI:MGI:1929286
See related
Ensembl:ENSMUSG00000032531 AllianceGenome:MGI:1929286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lccp; MASCOT; mKIAA0989
Summary
Enables actin filament binding activity and identical protein binding activity. Involved in endothelial cell morphogenesis. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including brain ventricular layer; dorsal aorta; gonad; telencephalon; and trophectoderm. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 51.4), lung adult (RPKM 30.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Amotl2 in Genome Data Viewer
Location:
9 F1; 9 54.71 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102594290..102610616)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102717091..102733418)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:102528825-102529014 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene VISTA enhancer mm1302 Neighboring gene STARR-seq mESC enhancer starr_25068 Neighboring gene predicted gene, 46150 Neighboring gene STARR-seq mESC enhancer starr_25069 Neighboring gene predicted gene 5627 Neighboring gene predicted gene, 46151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation. Fang P, et al. Environ Toxicol, 2021 Nov. PMID 34323359
  2. AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion. Mojallal M, et al. Nat Commun, 2014 Aug 1. PMID 25080976
  3. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. Wang Y, et al. J Biol Chem, 2011 Nov 25. PMID 21937427, Free PMC Article
  4. Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation. Matsumoto H, et al. J Reprod Dev, 2012. PMID 22813598
  5. The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms. Zhang Y, et al. Nat Cardiovasc Res, 2023 Jul. PMID 39195920, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
    Title: The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
  2. AMOTL2 restrains transforming growth factor-beta1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
    Title: AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
  3. mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
    Title: Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
  4. AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
    Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
  5. Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
    Title: Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
  6. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
    Title: Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.
  7. Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
    Title: Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
angiomotin-like protein 2
Names
Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421298.1 → NP_001408227.1  angiomotin-like protein 2

    Status: VALIDATED

    Source sequence(s)
    CT573150
    UniProtKB/Swiss-Prot
    B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0

  2. NM_001421301.1 → NP_001408230.1  angiomotin-like protein 2

    Status: VALIDATED

    Source sequence(s)
    CT573150
    UniProtKB/Swiss-Prot
    B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0
    Related
    ENSMUSP00000121113.2, ENSMUST00000153965.8

  3. NM_019764.2 → NP_062738.2  angiomotin-like protein 2

    See identical proteins and their annotated locations for NP_062738.2

    Status: VALIDATED

    Source sequence(s)
    AK141348, BB726257
    Consensus CDS
    CCDS40745.1
    UniProtKB/Swiss-Prot
    B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0
    UniProtKB/TrEMBL
    B8JK87
    Related
    ENSMUSP00000035121.8, ENSMUST00000035121.14
    Conserved Domains (2) summary
    COG1196
    Location:301 → 578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:478 → 679
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    102594290..102610616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511772.4 → XP_006511835.1  angiomotin-like protein 2 isoform X2

    UniProtKB/TrEMBL
    B8JK87
    Conserved Domains (2) summary
    COG1196
    Location:324 → 601
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:501 → 702
    Angiomotin_C; Angiomotin C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K371.1 GenPept UniProtKB/Swiss-Prot:Q8K371

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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