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grin2aa glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a [ Danio rerio (zebrafish) ]

Gene ID: 563297, updated on 12-Sep-2024

Summary

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Official Symbol
grin2aaprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070424-129
See related
Ensembl:ENSDARG00000034493 AllianceGenome:ZFIN:ZDB-GENE-070424-129
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-13c14.1
Summary
Predicted to enable NMDA glutamate receptor activity. Predicted to be involved in excitatory postsynaptic potential and long-term synaptic potentiation. Predicted to act upstream of or within ion transport. Predicted to be located in postsynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Huntington's disease; bipolar disorder; and schizophrenia. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See grin2aa in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (27072093..27277683)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (27029540..27144020)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108182821 Neighboring gene epithelial membrane protein 2 Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene uncharacterized LOC137490601 Neighboring gene HUWE1 associated protein modifying stress responses a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish. Zoodsma JD, et al. Mol Autism, 2022 Sep 22. PMID 36138431, Free PMC Article
  2. Evaluation of age-dependent response to NMDA receptor antagonism in zebrafish. Menezes FP, et al. Zebrafish, 2015 Apr. PMID 25602300
  3. Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Cox JA, et al. Dev Dyn, 2005 Nov. PMID 16123982
  4. Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Liu C, et al. Front Neurosci, 2021. PMID 34566559, Free PMC Article
  5. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A
Names
NR2A.2
zNMDA-2A.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    27072093..27277683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218021.1 → XP_068074122.1  glutamate receptor ionotropic, NMDA 2A

  2. XM_021473854.2 → XP_021329529.1  glutamate receptor ionotropic, NMDA 2A

    UniProtKB/TrEMBL
    A0A8M9PXD6
    Related
    ENSDARP00000116766.2, ENSDART00000142141.5
    Conserved Domains (3) summary
    cd06378
    Location:33 → 389
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:400 → 799
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:836 → 1460
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
Nucleotide Protein Strain
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