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lrp1aa low density lipoprotein receptor-related protein 1Aa [ Danio rerio (zebrafish) ]

Gene ID: 563149, updated on 17-Aug-2024

Summary

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Official Symbol
lrp1aaprovided by ZNC
Official Full Name
low density lipoprotein receptor-related protein 1Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7889
See related
Ensembl:ENSDARG00000097827 AllianceGenome:ZFIN:ZDB-GENE-030131-7889
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lrp1a; wu:fj39b01; si:dkey-40c23.4
Summary
Predicted to enable apolipoprotein binding activity and cargo receptor activity. Acts upstream of or within regulation of vasculature development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in blood vessel and caudal vein plexus. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
87
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1628524..1864384)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1601937..1867395)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene deltex E3 ubiquitin ligase 3L b, tandem duplicate 2 Neighboring gene deltex E3 ubiquitin ligase 3L b, tandem duplicate 3 Neighboring gene RNA binding motif, single stranded interacting protein 2a Neighboring gene Fas apoptotic inhibitory molecule 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Pi X, et al. Circ Res, 2012 Aug 17. PMID 22777006, Free PMC Article
  2. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables apolipoprotein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta clearance by cellular catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amyloid-beta clearance by transcytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 1
Names
low density lipoprotein receptor-related protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    1628524..1864384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479679.1 → XP_021335354.1  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 1

    UniProtKB/TrEMBL
    A0A8M9QD95
    Conserved Domains (9) summary
    smart00192
    Location:2818 → 2850
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:3183 → 3224
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:2983 → 3013
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3537 → 3571
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:4014 → 4054
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl00104
    Location:2530 → 2559
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam12662
    Location:2963 → 2986
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:3295 → 3331
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl26742
    Location:2235 → 2439
    SGL; SMP-30/Gluconolaconase/LRE-like region
Nucleotide Protein Strain
Heading Accession and Version

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