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plcl1 phospholipase C like 1 [ Danio rerio (zebrafish) ]

Gene ID: 563105, updated on 2-Nov-2024

Summary

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Official Symbol
plcl1provided by ZNC
Official Full Name
phospholipase C like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-194
See related
Ensembl:ENSDARG00000067676 AllianceGenome:ZFIN:ZDB-GENE-090313-194
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-15m21.1
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway and regulation of GABAergic synaptic transmission. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Is expressed in hindbrain; lateral line nerve; and spinal cord. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See plcl1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (32358335..32457840)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (32547227..32650103)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2 Neighboring gene SATB homeobox 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Takada N, et al. Dev Dyn, 2010 Jul. PMID 20549738
  2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive phospholipase C-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    32358335..32457840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921763.8 → XP_001921798.4  inactive phospholipase C-like protein 1

    UniProtKB/TrEMBL
    A0A8M1QKN6
    Related
    ENSDARP00000115360.2, ENSDART00000144608.3
    Conserved Domains (5) summary
    cd00275
    Location:766 → 894
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02952
    Location:302 → 889
    PLN02952; phosphoinositide phospholipase C
    cd13364
    Location:94 → 202
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:302 → 384
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:384 → 734
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
Nucleotide Protein
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