IL36G interleukin 36 gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL36Gprovided by HGNC
Official Full Name: interleukin 36 gammaprovided by HGNC
Primary source: HGNC:HGNC:15741
See related: Ensembl:ENSG00000136688 MIM:605542; AllianceGenome:HGNC:15741
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019]
Expression: Biased expression in skin (RPKM 3.5) and esophagus (RPKM 1.0) See more
Orthologs: mouse all
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Genomic context

Location:: 2q14.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (112978006..112985658)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (113404536..113412188)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (113735583..113743235)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mature IL-36gamma Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin.
Title: Mature IL-36γ Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin.
Interleukin-36gamma Mediates the In Vitro Activation of CD8[+] T Cells from Patients Living with Chronic Human Immunodeficiency Virus-1 Infection.
Title: Interleukin-36gamma Mediates the In Vitro Activation of CD8(+) T Cells from Patients Living with Chronic Human Immunodeficiency Virus-1 Infection.
Human interleukin-36gamma plays a crucial role in cytokine induction during Sporothrix brasiliensis and S. schenckii infection in keratinocytes and PBMCs.
Title: Human interleukin-36γ plays a crucial role in cytokine induction during Sporothrix brasiliensis and S. schenckii infection in keratinocytes and PBMCs.
IL-36gamma Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
Title: IL-36γ Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor-Vascular Endothelial Growth Factor Receptor Axis.
Role of interleukin-36gamma induced by ultraviolet radiation in chronic actinic dermatitis.
Title: Role of interleukin-36γ induced by ultraviolet radiation in chronic actinic dermatitis.
IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis.
Title: IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis.
Oleic acid-induced interleukin-36gamma: A possible link between facial skin redness and sebum.
Title: Oleic acid-induced interleukin-36γ: A possible link between facial skin redness and sebum.
The role of interleukin 36gamma in the epithelial-mesenchymal transition process of chronic rhinosinusitis: A pilot study.
Title: The role of interleukin 36γ in the epithelial-mesenchymal transition process of chronic rhinosinusitis: A pilot study.
Clinical significance of elevated serum IL-36gamma levels in patients with early-stage Hashimoto's thyroiditis.
Title: Clinical significance of elevated serum IL-36γ levels in patients with early-stage Hashimoto's thyroiditis.
Treponema denticola Induces Interleukin-36gamma Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-kappaB and Mitogen-Activated Protein Kinase Pathways.
Title: Treponema denticola Induces Interleukin-36γ Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-κB and Mitogen-Activated Protein Kinase Pathways.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of interleukin 36, gamma (IL36G) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed
Knockdown of interleukin 36, gamma (IL36G) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show upregulation of interleukin 36, gamma (IL36G) expression as compared to untreated control	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of interleukin 36, gamma (IL36G; IL-1F9) in peptide-treated PBMCs	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

IL-1H1_156 (e-PCR)
- UniSTS:277361

SHGC-17728 (e-PCR)
- UniSTS:44728

NoName (e-PCR)
- UniSTS:480971

SHGC-132256 (e-PCR)
- UniSTS:170739

NoName (e-PCR)
- UniSTS:482810

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: interleukin-36 gamma

Names: IL-1 related protein 2; IL-1-epsilon; interleukin 1-related protein 2; interleukin-1 epsilon; interleukin-1 family member 9; interleukin-1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278568.2 → NP_001265497.1 interleukin-36 gamma isoform 2

See identical proteins and their annotated locations for NP_001265497.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC016724, AF206696

Consensus CDS

CCDS62992.1

UniProtKB/Swiss-Prot

Q9NZH8

Related

ENSP00000365672.2, ENST00000376489.6

Conserved Domains (1) summary

cl00094
Location:22 → 123

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_019618.4 → NP_062564.1 interleukin-36 gamma isoform 1

See identical proteins and their annotated locations for NP_062564.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC016724, AF206696

Consensus CDS

CCDS2108.1

UniProtKB/Swiss-Prot

Q56B91, Q6UVX7, Q7RTZ9, Q9NZH8

Related

ENSP00000259205.3, ENST00000259205.5

Conserved Domains (1) summary

cl00094
Location:26 → 153

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).