Styx serine/threonine/tyrosine interaction protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Styxprovided by MGI
Official Full Name: serine/threonine/tyrosine interaction proteinprovided by MGI
Primary source: MGI:MGI:1891150
See related: Ensembl:ENSMUSG00000053205 AllianceGenome:MGI:1891150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hStyxb; 0610039A20Rik
Summary: Predicted to enable F-box domain binding activity and pseudophosphatase activity. Acts upstream of or within spermatogenesis. Located in cytoplasm. Orthologous to human STYX (serine/threonine/tyrosine interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 7.8), limb E14.5 (RPKM 6.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 22.9 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45588534..45614608)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (45351186..45376884)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function.
Title: Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function.
We demonstrate that the phosphoserine, -threonine or -tyrosine, interaction protein, Styx, complexes with a testicular RNA-binding protein and is essential for normal spermiogenesis.
Title: The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables F-box domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pseudophosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine/tyrosine-interacting protein

Names: inactive tyrosine-protein phosphatase Styx; phosphoserine/threonine/tyrosine interaction protein; protein tyrosine phosphatase-like protein; protein tyrosine phosphatase-like unspliced c-terminal product and spliced c-terminal end STYX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019637.3 → NP_062611.2 serine/threonine/tyrosine-interacting protein

See identical proteins and their annotated locations for NP_062611.2

Status: VALIDATED

Source sequence(s)

AC154575, CT025535

Consensus CDS

CCDS26975.1

UniProtKB/Swiss-Prot

Q3TMA3, Q60969, Q60970, Q9DCF8

UniProtKB/TrEMBL

Q3U4N1

Related

ENSMUSP00000153854.2, ENSMUST00000226873.2

Conserved Domains (1) summary

cd14522
Location:25 → 175

DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

45588534..45614608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158766.1 → XP_036014659.1 serine/threonine/tyrosine-interacting protein isoform X1

UniProtKB/TrEMBL

A0A2K6EDL3

Related

ENSMUSP00000107466.4, ENSMUST00000111835.4

Conserved Domains (1) summary

cd14522
Location:25 → 168

DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein