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Gkap1 G kinase anchoring protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56278, updated on 2-Nov-2024

Summary

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Official Symbol
Gkap1provided by MGI
Official Full Name
G kinase anchoring protein 1provided by MGI
Primary source
MGI:MGI:1891694
See related
Ensembl:ENSMUSG00000021552 AllianceGenome:MGI:1891694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
42kDa; Gkap42; D13Ertd340e; 4933400B15Rik
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of insulin receptor signaling pathway and signal transduction. Located in Golgi apparatus. Is expressed in several structures, including aorta; genitourinary system; gut gland; nervous system; and trachea. Orthologous to human GKAP1 (G kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 36.7), placenta adult (RPKM 11.9) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Gkap1 in Genome Data Viewer
Location:
13 B1; 13 30.97 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58381160..58422691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58233346..58274877, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 Neighboring gene STARR-seq mESC enhancer starr_34674 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34675 Neighboring gene STARR-seq mESC enhancer starr_34676 Neighboring gene predicted gene, 26555 Neighboring gene STARR-seq mESC enhancer starr_34677 Neighboring gene kinesin family member 27 Neighboring gene STARR-seq mESC enhancer starr_34678 Neighboring gene microRNA 6369 Neighboring gene STARR-seq mESC enhancer starr_34680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58474531-58474732 Neighboring gene Q-nucleotide N-glycosylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional role of GKAP1 in the regulation of male germ cell spontaneous apoptosis and sperm number. Wang H, et al. Mol Reprod Dev, 2019 Sep. PMID 31318116
  2. Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Ando Y, et al. J Biol Chem, 2015 Feb 27. PMID 25586176, Free PMC Article
  3. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. Yuasa K, et al. J Biol Chem, 2000 Feb 18. PMID 10671526
  4. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Zhao X, et al. Cell Res, 2014 Dec. PMID 25412662, Free PMC Article
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G kinase-anchoring protein 1
Names
42 kD cGMP-dependent protein kinase anchoring protein
cGMP-dependent protein kinase anchoring protein
cGMP-dependent protein kinase-anchoring protein of 42 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019832.4 → NP_062806.1  G kinase-anchoring protein 1

    See identical proteins and their annotated locations for NP_062806.1

    Status: VALIDATED

    Source sequence(s)
    BC052347, W84281
    Consensus CDS
    CCDS36684.1
    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Related
    ENSMUSP00000089169.5, ENSMUST00000091579.6
    Conserved Domains (1) summary
    COG1196
    Location:188 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58381160..58422691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244542.3 → XP_011242844.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242844.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_030247329.2 → XP_030103189.1  G kinase-anchoring protein 1 isoform X2

  3. XM_006517304.5 → XP_006517367.1  G kinase-anchoring protein 1 isoform X2

  4. XM_030247330.2 → XP_030103190.1  G kinase-anchoring protein 1 isoform X2

  5. XM_011244543.4 → XP_011242845.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242845.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_036158099.1 → XP_036013992.1  G kinase-anchoring protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006517301.3 → XP_006517364.1  G kinase-anchoring protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006517364.1

    UniProtKB/Swiss-Prot
    Q9CUD8, Q9JMB0
    Conserved Domains (1) summary
    COG1196
    Location:188 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMB0.1 GenPept UniProtKB/Swiss-Prot:Q9JMB0

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