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slc12a10.3 solute carrier family 12 member 10, tandem duplicate 3 [ Danio rerio (zebrafish) ]

Gene ID: 562763, updated on 2-Nov-2024

Summary

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Official Symbol
slc12a10.3provided by ZNC
Official Full Name
solute carrier family 12 member 10, tandem duplicate 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-518
See related
Ensembl:ENSDARG00000055253 AllianceGenome:ZFIN:ZDB-GENE-060503-518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-114c3.3
Summary
Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in eye and kidney. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See slc12a10.3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (4384835..4420201)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (4246837..4282175)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch211-63p21.8 Neighboring gene solute carrier family 12 member 10, tandem duplicate 2 Neighboring gene 5S ribosomal RNA Neighboring gene solute carrier family 12 member 10, tandem duplicate 1 Neighboring gene uncharacterized LOC137496122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A new model for fish ion regulation: identification of ionocytes in freshwater- and seawater-acclimated medaka (Oryzias latipes). Hsu HH, et al. Cell Tissue Res, 2014 Jul. PMID 24842048
  2. Role of SLC12A10.2, a Na-Cl cotransporter-like protein, in a Cl uptake mechanism in zebrafish (Danio rerio). Wang YF, et al. Am J Physiol Regul Integr Comp Physiol, 2009 May. PMID 19279294
  3. Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. Wang YF, et al. Int J Biol Sci, 2015. PMID 26327813, Free PMC Article
  4. Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Arcanjo C, et al. Aquat Toxicol, 2018 Jul. PMID 29751158
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC175183

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 10, tandem duplicate 3
Names
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135131.2 → NP_001128603.2  solute carrier family 12 member 10, tandem duplicate 3

    Status: VALIDATED

    Source sequence(s)
    CR383683
    Related
    ENSDARP00000118237.2, ENSDART00000134653.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    4384835..4420201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477565.2 → XP_021333240.1  solute carrier family 12 member 10, tandem duplicate 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QH36, B5DE35
    Conserved Domains (1) summary
    cl27256
    Location:54 → 1000
    SLC12; Solute carrier family 12
Nucleotide Protein Strain
Heading Accession and Version

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