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Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 [ Mus musculus (house mouse) ]

Gene ID: 56258, updated on 2-Nov-2024

Summary

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Official Symbol
Hnrnph2provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein H2provided by MGI
Primary source
MGI:MGI:1201779
See related
Ensembl:ENSMUSG00000045427 AllianceGenome:MGI:1201779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H'; Ftp3; Ftp-3; HNRNP; Hnrph2; DXHXS1271E
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm and postsynaptic density. Is expressed in brain; heart; olfactory epithelium; and spinal cord. Used to study syndromic X-linked intellectual developmental disorder bain type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual developmental disorder bain type. Orthologous to human HNRNPH2 (heterogeneous nuclear ribonucleoprotein H2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 40.2), liver E14 (RPKM 35.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnph2 in Genome Data Viewer
Location:
X E3; X 56.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133501928..133507809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134601179..134607060)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47960 Neighboring gene ribosomal protein L36A Neighboring gene galactosidase, alpha Neighboring gene STARR-positive B cell enhancer mm9_chrX:131135522-131135823 Neighboring gene predicted gene 7855 Neighboring gene predicted gene, 19502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene. Hamada T, et al. J Physiol Sci, 2015 Jul. PMID 25846207, Free PMC Article
  2. Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. Oeltjen JC, et al. Mamm Genome, 1995 May. PMID 7626884
  3. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. Ruan QT, et al. J Neurosci, 2020 Jan 2. PMID 31704785, Free PMC Article
  4. Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Oeltjen JC, et al. Genome Res, 1997 Apr. PMID 9110171
  5. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. Loeb CR, et al. J Biol Chem, 2006 Sep 22. PMID 16798735

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
    Title: A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1.
  2. hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).
    Title: Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H2
Names
heterogeneous nuclear ribonucleoprotein H'
hnRNP H'
hnRNP H2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313716.1 → NP_001300645.1  heterogeneous nuclear ribonucleoprotein H2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AI853236, AK077716, BB844564, BX004852
    Consensus CDS
    CCDS30397.1
    UniProtKB/Swiss-Prot
    P70333, Q3THV9
    Related
    ENSMUSP00000074483.5, ENSMUST00000074950.11
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  2. NM_001313717.1 → NP_001300646.1  heterogeneous nuclear ribonucleoprotein H2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AI853236, AK077716, BX004852, BY227927
    Consensus CDS
    CCDS30397.1
    UniProtKB/Swiss-Prot
    P70333, Q3THV9
    Related
    ENSMUSP00000108829.2, ENSMUST00000113203.2
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  3. NM_019868.4 → NP_063921.1  heterogeneous nuclear ribonucleoprotein H2

    See identical proteins and their annotated locations for NP_063921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AI853236, AK077716, BX004852, BY135797
    Consensus CDS
    CCDS30397.1
    UniProtKB/Swiss-Prot
    P70333, Q3THV9
    Related
    ENSMUSP00000050838.6, ENSMUST00000059297.6
    Conserved Domains (4) summary
    pfam08080
    Location:257 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133501928..133507809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70333.1 GenPept UniProtKB/Swiss-Prot:P70333

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