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RNF20 ring finger protein 20 [ Homo sapiens (human) ]

Gene ID: 56254, updated on 3-Nov-2024

Summary

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Official Symbol
RNF20provided by HGNC
Official Full Name
ring finger protein 20provided by HGNC
Primary source
HGNC:HGNC:10062
See related
Ensembl:ENSG00000155827 MIM:607699; AllianceGenome:HGNC:10062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRE1; BRE1A; hBRE1
Summary
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in testis (RPKM 16.7), brain (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

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See RNF20 in Genome Data Viewer
Location:
9q31.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (101533853..101563344)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (113708604..113738115)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (104296135..104325626)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:104223504-104224020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:104224021-104224537 Neighboring gene NFE2L2 motif-containing MPRA enhancer 257 Neighboring gene TMEM246 antisense RNA 1 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:104275376-104275886 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:104275887-104276395 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:104276396-104276905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:104286647-104287146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28726 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:104316489-104316706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28727 Neighboring gene glutamate ionotropic receptor NMDA type subunit 3A Neighboring gene uncharacterized LOC105376186 Neighboring gene protein phosphatase 3 regulatory subunit B, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Lossos IS, et al. Proc Natl Acad Sci U S A, 2000 Aug 29. PMID 10954754, Free PMC Article
  2. CircRNF20 aggravates the progression of non-small-cell lung carcinoma by activating MAPK9. Wang ZX, et al. Eur Rev Med Pharmacol Sci, 2020 Oct. PMID 33090403
  3. Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer. Hooda J, et al. Cancer Res, 2019 Feb 15. PMID 30563893, Free PMC Article
  4. Role of RNF20 in cancer development and progression - a comprehensive review. Sethi G, et al. Biosci Rep, 2018 Aug 31. PMID 29934362, Free PMC Article
  5. RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer. Tarcic O, et al. Cell Death Differ, 2017 Apr. PMID 28157208, Free PMC Article

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
    Title: Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
  2. RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer.
    Title: RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer.
  3. RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles.
    Title: RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles.
  4. Structure of the human Bre1 complex bound to the nucleosome.
    Title: Structure of the human Bre1 complex bound to the nucleosome.
  5. RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization.
    Title: RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization.
  6. Iron deficiency-induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification.
    Title: Iron deficiency-induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification.
  7. RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
    Title: RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
  8. The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
    Title: The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.
  9. Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination.
    Title: Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination.
  10. Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1.
    Title: Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify E3 ubiquitin protein ligase ring finger protein 20 (RNF20; BRE1A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11189, FLJ20382, KIAA2779, MGC129667, MGC129668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase BRE1A
Names
BRE1 E3 ubiquitin ligase homolog
RING-type E3 ubiquitin transferase BRE1A
homolog of S. cerevisiae BRE1
NP_062538.5
XP_011517164.1
XP_047279550.1
XP_054219263.1
XP_054219264.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047002.1 RefSeqGene

    Range
    5005..34496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019592.7 → NP_062538.5  E3 ubiquitin-protein ligase BRE1A

    See identical proteins and their annotated locations for NP_062538.5

    Status: REVIEWED

    Source sequence(s)
    AF265230, AL832910, BC110584
    Consensus CDS
    CCDS35084.1
    UniProtKB/Swiss-Prot
    A7MCT5, Q2TB34, Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83
    Related
    ENSP00000373772.3, ENST00000389120.8
    Conserved Domains (3) summary
    COG1196
    Location:622 → 920
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:44 → 759
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16704
    Location:920 → 965
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    101533853..101563344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518862.2 → XP_011517164.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_011517164.1

    UniProtKB/Swiss-Prot
    A7MCT5, Q2TB34, Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83
    Conserved Domains (3) summary
    COG1196
    Location:622 → 920
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:44 → 759
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16704
    Location:920 → 965
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  2. XM_047423594.1 → XP_047279550.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    UniProtKB/Swiss-Prot
    A7MCT5, Q2TB34, Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    113708604..113738115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363289.1 → XP_054219264.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    UniProtKB/Swiss-Prot
    A7MCT5, Q2TB34, Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83

  2. XM_054363288.1 → XP_054219263.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    UniProtKB/Swiss-Prot
    A7MCT5, Q2TB34, Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VTR2.2 GenPept UniProtKB/Swiss-Prot:Q5VTR2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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