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Hdac7 histone deacetylase 7 [ Mus musculus (house mouse) ]

Gene ID: 56233, updated on 2-Nov-2024

Summary

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Official Symbol
Hdac7provided by MGI
Official Full Name
histone deacetylase 7provided by MGI
Primary source
MGI:MGI:1891835
See related
Ensembl:ENSMUSG00000022475 AllianceGenome:MGI:1891835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik
Summary
Enables chromatin binding activity; histone deacetylase activity; and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Is active in nucleus. Is expressed in several structures, including adrenal gland; cerebral cortex; heart; and sensory organ. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Hdac7 in Genome Data Viewer
Location:
15 F1; 15 53.79 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97690542..97742383, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97792661..97844502, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene predicted gene, 46535 Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10877 Neighboring gene STARR-positive B cell enhancer ABC_E1916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97659351-97659504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97666932-97667248 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene STARR-seq mESC enhancer starr_39643 Neighboring gene vitamin D (1,25-dihydroxyvitamin D3) receptor Neighboring gene predicted gene, 52171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance. Kasler HG, et al. EMBO J, 2012 Nov 28. PMID 23103766, Free PMC Article
  2. SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation. Helms RS, et al. J Immunol, 2023 Dec 15. PMID 37947442,
  3. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Axisa PP, et al. Sci Transl Med, 2022 Dec 14. PMID 36516268
  4. Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Navarro MN, et al. Nat Immunol, 2011 Apr. PMID 21399638, Free PMC Article
  5. HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Ye J, et al. Mol Neurobiol, 2022 Oct. PMID 35871708, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
    Title: Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
  2. SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
    Title: SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
  3. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
    Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
  4. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
    Title: A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
  5. HDAC7 Activates IKK/NF-kappaB Signaling to Regulate Astrocyte-Mediated Inflammation.
    Title: HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation.
  6. Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
    Title: Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
  7. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
    Title: Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
  8. HDAC7 is a bona fide transcriptional repressor essential for B cell development.
    Title: In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
  9. In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning.
    Title: HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation.
  10. This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy.
    Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables 14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein lysine deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
 PubMed 
involved_in B cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell-cell junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of striated muscle tissue development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deacetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 7
Names
histone deacetylase 7A
protein deacetylase HDAC7
NP_001191204.1
NP_001191205.1
NP_001191206.1
NP_001191207.1
NP_001191208.1
NP_001191209.1
NP_001191210.1
NP_001365900.1
NP_062518.2
XP_006521268.1
XP_006521270.1
XP_006521271.1
XP_006521272.1
XP_006521273.1
XP_030104529.1
XP_036015418.1
XP_036015419.1
XP_036015420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204275.1 → NP_001191204.1  histone deacetylase 7 isoform 1

    See identical proteins and their annotated locations for NP_001191204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57006.1
    UniProtKB/TrEMBL
    Q6KAT4
    Related
    ENSMUSP00000112110.3, ENSMUST00000116409.9
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001204276.1 → NP_001191205.1  histone deacetylase 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57005.1
    UniProtKB/TrEMBL
    Q6KAT4
    Related
    ENSMUSP00000113380.2, ENSMUST00000118294.8
    Conserved Domains (1) summary
    cd10008
    Location:515 → 890
    HDAC7; Histone deacetylase 7

  3. NM_001204277.1 → NP_001191206.1  histone deacetylase 7 isoform 3

    See identical proteins and their annotated locations for NP_001191206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK044287, BB648696
    Consensus CDS
    CCDS57007.1
    UniProtKB/TrEMBL
    Q6KAT4
    Related
    ENSMUSP00000078766.8, ENSMUST00000079838.14
    Conserved Domains (1) summary
    cd10008
    Location:513 → 888
    HDAC7; Histone deacetylase 7

  4. NM_001204278.1 → NP_001191207.1  histone deacetylase 7 isoform 5

    See identical proteins and their annotated locations for NP_001191207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57004.1
    UniProtKB/TrEMBL
    Q6KAT4
    Related
    ENSMUSP00000112109.3, ENSMUST00000116408.9
    Conserved Domains (1) summary
    cd10008
    Location:485 → 860
    HDAC7; Histone deacetylase 7

  5. NM_001204279.1 → NP_001191208.1  histone deacetylase 7 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57001.1
    UniProtKB/TrEMBL
    E9PXW1, Q6KAT4
    Related
    ENSMUSP00000112459.2, ENSMUST00000119670.8
    Conserved Domains (1) summary
    cd10008
    Location:461 → 836
    HDAC7; Histone deacetylase 7

  6. NM_001204280.1 → NP_001191209.1  histone deacetylase 7 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57003.1
    UniProtKB/TrEMBL
    E9PXW8, Q6KAT4
    Related
    ENSMUSP00000112446.2, ENSMUST00000120683.8
    Conserved Domains (1) summary
    cl17011
    Location:485 → 812
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  7. NM_001204281.1 → NP_001191210.1  histone deacetylase 7 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
    Source sequence(s)
    AC158787
    Consensus CDS
    CCDS57002.1
    UniProtKB/TrEMBL
    E9PX62, Q6KAT4
    Related
    ENSMUSP00000112641.2, ENSMUST00000121514.8
    Conserved Domains (1) summary
    cd10008
    Location:420 → 795
    HDAC7; Histone deacetylase 7

  8. NM_001378971.1 → NP_001365900.1  histone deacetylase 7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158787
    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:544 → 919
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:122 → 525
    PHA03247; large tegument protein UL36; Provisional

  9. NM_019572.3 → NP_062518.2  histone deacetylase 7 isoform 4

    See identical proteins and their annotated locations for NP_062518.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK044287, BB648696, BC057332
    Consensus CDS
    CCDS37188.1
    UniProtKB/Swiss-Prot
    Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72
    UniProtKB/TrEMBL
    Q6KAT4
    Related
    ENSMUSP00000085744.6, ENSMUST00000088402.12
    Conserved Domains (1) summary
    cd10008
    Location:507 → 882
    HDAC7; Histone deacetylase 7

RNA

  1. NR_166212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158787

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97690542..97742383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159526.1 → XP_036015419.1  histone deacetylase 7 isoform X4

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:500 → 875
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:122 → 499
    PHA03247; large tegument protein UL36; Provisional

  2. XM_030248669.2 → XP_030104529.1  histone deacetylase 7 isoform X3

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:511 → 886
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:20 → 492
    PHA03247; large tegument protein UL36; Provisional

  3. XM_006521210.4 → XP_006521273.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521273.1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  4. XM_036159527.1 → XP_036015420.1  histone deacetylase 7 isoform X5

    UniProtKB/TrEMBL
    Q3UJT5
    Conserved Domains (1) summary
    cd10008
    Location:96 → 471
    HDAC7; Histone deacetylase 7

  5. XM_006521208.5 → XP_006521271.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521271.1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  6. XM_006521205.3 → XP_006521268.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521268.1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  7. XM_006521209.3 → XP_006521272.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521272.1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  8. XM_006521207.5 → XP_006521270.1  histone deacetylase 7 isoform X2

    See identical proteins and their annotated locations for XP_006521270.1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:522 → 897
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:100 → 503
    PHA03247; large tegument protein UL36; Provisional

  9. XM_036159525.1 → XP_036015418.1  histone deacetylase 7 isoform X1

    UniProtKB/TrEMBL
    Q6KAT4
    Conserved Domains (2) summary
    cd10008
    Location:546 → 921
    HDAC7; Histone deacetylase 7
    PHA03247
    Location:124 → 527
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_003951412.1 RNA Sequence

  2. XR_003951415.1 RNA Sequence

  3. XR_003951414.1 RNA Sequence

  4. XR_003951413.1 RNA Sequence

    Related
    ENSMUST00000228466.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C2B3.2 GenPept UniProtKB/Swiss-Prot:Q8C2B3

Gene LinkOut

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