Fscn3 fascin actin-bundling protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fscn3provided by MGI
Official Full Name: fascin actin-bundling protein 3provided by MGI
Primary source: MGI:MGI:1890386
See related: Ensembl:ENSMUSG00000029707 AllianceGenome:MGI:1890386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to act upstream of or within spermatid development. Located in cytoplasm. Is expressed in testis. Orthologous to human FSCN3 (fascin actin-bundling protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 130.6) See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 11.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (28427888..28438621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (28427870..28438622)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
Title: Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
This is a novel, spermatid-specific murine paralog of the actin-binding protein fascin FSCN1. Its expression is restricted to the elongated spermatid head.
Title: Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

RH129669 (e-PCR)
- UniSTS:212966

stSG613726 (e-PCR)
- UniSTS:451834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISA Inferred from Sequence Alignment more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in growth cone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fascin-3

Names: fascin (testis); fascin homolog 3, actin-bundling protein, testicular; testis fascin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411255.1 → NP_001398184.1 fascin-3 isoform 2

Status: VALIDATED

Source sequence(s)

AC068608
NM_019569.3 → NP_062515.2 fascin-3 isoform 1

See identical proteins and their annotated locations for NP_062515.2

Status: VALIDATED

Source sequence(s)

AC068608

Consensus CDS

CCDS39446.1

UniProtKB/Swiss-Prot

Q80YU6, Q9QXW4

Related

ENSMUSP00000031719.7, ENSMUST00000031719.7

Conserved Domains (2) summary

cd00257
Location:263 → 381

Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...

pfam06268
Location:24 → 138

Fascin; Fascin domain