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ndufb11 NADH:ubiquinone oxidoreductase subunit B11 [ Danio rerio (zebrafish) ]

Gene ID: 562219, updated on 2-Nov-2024

Summary

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Official Symbol
ndufb11provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit B11provided by ZNC
Primary source
ZFIN:ZDB-GENE-050309-25
See related
Ensembl:ENSDARG00000043467 AllianceGenome:ZFIN:ZDB-GENE-050309-25
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6897973; si:dkey-6n6.4
Summary
Acts upstream of or within heart development and vasculature development. Predicted to be located in membrane. Predicted to be part of respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; digestive system; intestinal bulb primordium; optic tectum; and pectoral fin. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ndufb11 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (14180064..14184423, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (14142359..14146718, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-6n6.1 Neighboring gene thiamin pyrophosphokinase 2 Neighboring gene ras homolog gene family, member Aa Neighboring gene DEF6 guanine nucleotide exchange factor a Neighboring gene SIN3 transcription regulator family member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Exome sequencing of patients with histiocytoid cardiomyopathy reveals a de novo NDUFB11 mutation that plays a role in the pathogenesis of histiocytoid cardiomyopathy. Shehata BM, et al. Am J Med Genet A, 2015 Sep. PMID 25921236, Free PMC Article
  2. Regulation of spermatogonial development by Fsh: The complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. Safian D, et al. Gen Comp Endocrinol, 2019 Dec 1. PMID 31415728
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044981.1 → NP_001038446.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

    Status: PROVISIONAL

    Source sequence(s)
    BX004884
    UniProtKB/TrEMBL
    A0A8M1N9R9, Q1LYN0
    Related
    ENSDARP00000063816.6, ENSDART00000063817.7
    Conserved Domains (1) summary
    pfam10183
    Location:26 → 129
    ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    14180064..14184423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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