trpc2b transient receptor potential cation channel subfamily C member 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trpc2bprovided by ZNC
Official Full Name: transient receptor potential cation channel subfamily C member 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050712-3
See related: Ensembl:ENSDARG00000003344 AllianceGenome:ZFIN:ZDB-GENE-050712-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trpc2; trpc2a
Summary: Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane. Is expressed in microvillous olfactory receptor neurons; olfactory epithelium; olfactory receptor cell; and olfactory rosette. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (30746348..30765533)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (30709653..30730911)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily C member 2b

Names: transient receptor potential cation channel subfamily c member 2a; transient receptor potential cation channel, subfamily C, member 2; transient receptor potential channel C2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030166.1 → NP_001025337.1 transient receptor potential cation channel subfamily C member 2b

See identical proteins and their annotated locations for NP_001025337.1

Status: PROVISIONAL

Source sequence(s)

AY974804

UniProtKB/TrEMBL

Q4VDB0

Related

ENSDARP00000050171.6, ENSDART00000050172.7

Conserved Domains (4) summary

cd00204
Location:26 → 159

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:23 → 762

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:174 → 233

TRP_2; Transient receptor ion channel II

sd00045
Location:60 → 87

ANK; ANK repeat [structural motif]