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hspa4l heat shock protein 4 like [ Danio rerio (zebrafish) ]

Gene ID: 562019, updated on 12-Sep-2024

Summary

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Official Symbol
hspa4lprovided by ZNC
Official Full Name
heat shock protein 4 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2412
See related
Ensembl:ENSDARG00000053544 AllianceGenome:ZFIN:ZDB-GENE-030131-2412
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc07b10; wu:fc07b10; si:dkey-21a6.6
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system and lens. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hspa4l in Genome Data Viewer
Location:
chromosome: 17
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43431020..43466288, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43439825..43475755, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene inositol-tetrakisphosphate 1-kinase b Neighboring gene polo-like kinase 4 (Drosophila) Neighboring gene charged multivesicular body protein 3 Neighboring gene receptor accessory protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Khan SY, et al. Nat Commun, 2016 Apr 6. PMID 27218149, Free PMC Article
  2. p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Gong L, et al. Cell Rep, 2019 Dec 10. PMID 31825845
  3. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
  4. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article
  5. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease in zebrafish. Sarath Babu N, et al. Proteomics, 2016 May. PMID 26959078

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock 70 kDa protein 4L

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    43431020..43466288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_685413.9 → XP_690505.2  heat shock 70 kDa protein 4L

    UniProtKB/TrEMBL
    A0A8N7T7F2, X1WBR5
    Related
    ENSDARP00000127657.1, ENSDART00000155313.2
    Conserved Domains (2) summary
    pfam00012
    Location:3 → 686
    HSP70; Hsp70 protein
    cl17037
    Location:2 → 384
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
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